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. 2024 Mar 27;25(3):bbae212.
doi: 10.1093/bib/bbae212.

DDID: a comprehensive resource for visualization and analysis of diet-drug interactions

Yanfeng Hong  1 , Hongquan Xu  1 , Yuhong Liu  1 , Sisi Zhu  1 , Chao Tian  1 , Gongxing Chen  1 , Feng Zhu  2   3 , Lin Tao  1
Affiliations

DDID: a comprehensive resource for visualization and analysis of diet-drug interactions

Yanfeng Hong et al. Brief Bioinform. .

Abstract

Diet-drug interactions (DDIs) are pivotal in drug discovery and pharmacovigilance. DDIs can modify the systemic bioavailability/pharmacokinetics of drugs, posing a threat to public health and patient safety. Therefore, it is crucial to establish a platform to reveal the correlation between diets and drugs. Accordingly, we have established a publicly accessible online platform, known as Diet-Drug Interactions Database (DDID, https://bddg.hznu.edu.cn/ddid/), to systematically detail the correlation and corresponding mechanisms of DDIs. The platform comprises 1338 foods/herbs, encompassing flora and fauna, alongside 1516 widely used drugs and 23 950 interaction records. All interactions are meticulously scrutinized and segmented into five categories, thereby resulting in evaluations (positive, negative, no effect, harmful and possible). Besides, cross-linkages between foods/herbs, drugs and other databases are furnished. In conclusion, DDID is a useful resource for comprehending the correlation between foods, herbs and drugs and holds a promise to enhance drug utilization and research on drug combinations.

Keywords: bioinformatics; daily intake; database; diet–drug interactions; drug safety.

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Figures

Figure 1
Figure 1
Workflow of DDID.
Figure 2
Figure 2
Flowchart of DDI relationships. The unique feature of DDID is to present the diet-drug interactions with reliable evaluations. The user can select three different aspects of the search (food, herb, or drug), according to their needs, all of which will provide comprehensive data and information.
Figure 3
Figure 3
The food detail page of DDID provides general information on the food, interactions, and links to several other reliable databases.
Figure 4
Figure 4
Pie charts illustrate the proportion of DDID's interactions accounted for by different sources of influence, describing the composition of the biological sources and their corresponding families, genera, and species numbers.
Figure 5
Figure 5
Statistical analysis of the top five plant families in DDID's herb sources. (A) the top five families and their species. (B) the top five families and their number of interactions.
Figure 6
Figure 6
Distribution of the physio-chemical properties of compounds in DDID. (A) Molecular weight, (B) Rotatable Bonds, (C) H-bond donors, and (D) H-bond acceptors.
See this image and copyright information in PMC

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