Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2024 Apr 22:15:1320632.
doi: 10.3389/fendo.2024.1320632. eCollection 2024.

Meta-analysis of the relationship between ocular and peripheral serum IL-17A and diabetic retinopathy

Xiaodong Li  1 , Wei Qin  2 , Xuewei Qin  1 , Dandan Wu  1 , Chenyuan Gao  1 , Yinyue Luo  1 , Mingchao Xu  3
Affiliations
Meta-Analysis

Meta-analysis of the relationship between ocular and peripheral serum IL-17A and diabetic retinopathy

Xiaodong Li et al. Front Endocrinol (Lausanne). .

Abstract

Purpose: A systematic evaluation and Meta-analysis were performed to determine the relationship between IL-17A levels in ocular aqueous and peripheral venous serum samples and diabetic retinopathy (DR).

Methods: PubMed, Embase, Web of Science, and CNKI databases were searched from the time of library construction to 2023-09-20.The results were combined using a random-effects model, sensitivity analyses were performed to determine whether the arithmetic was stable and reliable, and subgroup analyses were used to look for possible sources of heterogeneity.

Results: A total of 7 case-control studies were included. The level of IL-17A was higher in the Nonproliferative DR(NPDR) group than in the Non-DR(NDR) group [SMD=2.07,95%CI(0.45,3.68),P=0.01], and the level of IL-17A in the proliferating DR(PDR) group was higher than that of the NDR group [SMD=4.66,95%CI(1.23,8.08),P<0.00001]. IL-17A levels in peripheral serum and atrial fluid were significantly higher in NPDR and PDR patients than in non-DR patients in subgroup analyses, and detection of peripheral serum IL-17A concentrations could help to assess the risk of progression from NPDR to PDR. Sensitivity analyses suggested that the results of the random-effects arithmetic were stable and reliable. Subgroup analyses based on assay method and sample source showed that the choice of these factors would largely influence the relationship between IL-17A levels and DR.

Conclusion: Elevated peripheral serum and ocular aqueous humor IL-17A levels in diabetic patients are associated with the risk of DR, IL-17A may serve as a potential predictor or therapeutic target for DR, and IL-17A may be an important predictor of inflammation for the progression of NPDR to PDR.

Systematic review registration: https://www.crd.york.ac.uk/prospero/, identifier CRD42024532900.

Keywords: IL-17A; diabetic retinopathy; inflammatory factor; meta-analysis; system analysis.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flowchart of literature screening.
Figure 2
Figure 2
Forest plot of the relationship between IL-17A and NPDR.
Figure 3
Figure 3
Forest plot of IL-17A about PDR.
Figure 4
Figure 4
Subgroup analysis based on sample source (NDR-NPDR).
Figure 5
Figure 5
Subgroup analysis based on sample source (NDR-PDR).
Figure 6
Figure 6
Subgroup analysis based on sample source (NPDR-PDR).
Figure 7
Figure 7
Subgroup analysis based on detection methods (NDR-NPDR).
Figure 8
Figure 8
Subgroup analysis based on detection methods (NDR-PDR).
Figure 9
Figure 9
Funnel chart of included literature.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Teo Z, Tham Y, Yu M, Chee M, Rim T, Cheung N, et al. . Global prevalence of diabetic retinopathy and projection of burden through 2045: systematic review and meta-analysis. Ophthalmology. (2021) 128:1580–91. doi: 10.1016/j.ophtha.2021.04.027 - DOI - PubMed
    1. Forrester J, Kuffova L, Delibegovic M. The role of inflammation in diabetic retinopathy. Front Immunol. (2020) 11:583687. doi: 10.3389/fimmu.2020.583687 - DOI - PMC - PubMed
    1. Rübsam A, Parikh S, Fort P. Role of inflammation in diabetic retinopathy. Int J Mol Sci. (2018) 19:1816. doi: 10.3390/ijms19040942 - DOI - PMC - PubMed
    1. Wang W, Lo A. Diabetic retinopathy: pathophysiology and treatments. Int J Mol Sci. (2018) 19. doi: 10.3390/ijms19061816 - DOI - PMC - PubMed
    1. Youngblood H, Robinson R, Sharma A, Sharma S. Proteomic biomarkers of retinal inflammation in diabetic retinopathy. Int J Mol Sci. (2019) 20:4755. doi: 10.3390/ijms20194755 - DOI - PMC - PubMed

Publication types