The antigen receptor on a human T cell line initiates activation by increasing cytoplasmic free calcium
- PMID: 3871211
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The antigen receptor on a human T cell line initiates activation by increasing cytoplasmic free calcium
J Immunol.
1985 Feb.
Abstract
A monoclonal antibody to the antigen-receptor on the T cell line Jurkat induces substantial increases in [Ca++]i. Ca++ ionophores can substitute for this antibody in activation by increasing [Ca++]i to levels comparable with those seen with the antigen-receptor antibody. Stimulation with either the antigen-receptor antibody or a Ca++ ionophore leads to the appearance of the same phosphoproteins. These results suggest that the antigen-receptor initiates T cell activation by increasing [Ca++]i.
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