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. 2024 May 1;7(5):e2410162.
doi: 10.1001/jamanetworkopen.2024.10162.

Social Determinants of Health and the Availability of Cancer Clinical Trials in the United States

Rishi Robert Sekar  1   2   3 , Lindsey Allison Herrel  1   2 , Kristian Donald Stensland  1   2
Affiliations

Social Determinants of Health and the Availability of Cancer Clinical Trials in the United States

Rishi Robert Sekar et al. JAMA Netw Open. .
No abstract available

Plain language summary

This cohort study investigates whether county-level social determinants of health are associated with cancer clinical trial availability in the United States.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Sekar reported grants from the National Cancer Institute Training Grant T32-CA-236621 during the conduct of the study. Dr Herrel reported grants from the National Cancer Institute during the conduct of the study. Dr Stensland reported grants from the National Institutes of Health during the conduct of the study.

Figures

Figure 1.
Figure 1.. Adjusted Probability of Having Any Clinical Trial and Adjusted Mean Number of Cancer Clinical Trials by Social Vulnerability Index (SVI) Quintile
The figures show the adjusted probability of having any clinical trial by SVI quintile and the adjusted mean number of cancer clinical trials by SVI quintile, adjusting for county population, cancer incidence rates, and presence of Commission on Cancer hospitals.
Figure 2.
Figure 2.. Time Plot of the Proportion of Counties With Any Cancer Clinical Trial and Mean Number of Population-Adjusted Cancer Clinical Trials by Social Vulnerability Index (SVI) Quintile
The time plots (2007 to 2022) demonstrate the proportion of counties with any cancer clinical trial by SVI quintile and the mean number of population-adjusted (per 100 000 residents ≥50 years of age) cancer clinical trials by SVI quintile. Relevant rules and regulations for reporting of clinical trials in ClinicalTrials.gov: Food and Drug Administration Amendments Act (2007), Health and Human Services Final Rule (2017), and National Institutes of Health (NIH) Policy on the Dissemination of NIH-Funded Clinical Trial Information (2017).
See this image and copyright information in PMC

References

    1. Unger JM, Vaidya R, Hershman DL, Minasian LM, Fleury ME. Systematic review and meta-analysis of the magnitude of structural, clinical, and physician and patient barriers to cancer clinical trial participation. J Natl Cancer Inst. 2019;111(3):245-255. doi: 10.1093/jnci/djy221 - DOI - PMC - PubMed
    1. Gresham G, Meinert JL, Gresham AG, Meinert CL. Assessment of trends in the design, accrual, and completion of trials registered in ClinicalTrials.gov by sponsor type, 2000. JAMA Netw Open. 2020;3(8):e2014682. doi: 10.1001/jamanetworkopen.2020.14682 - DOI - PMC - PubMed
    1. Javier-DesLoges J, Nelson TJ, Murphy JD, et al. Disparities and trends in the participation of minorities, women, and the elderly in breast, colorectal, lung, and prostate cancer clinical trials. Cancer. 2022;128(4):770-777. doi: 10.1002/cncr.33991 - DOI - PubMed
    1. Loehrer AP, Green SR, Winkfield KM. Inequity in cancer and cancer care delivery in the United States. Hematol Oncol Clin North Am. Published online September 4, 2023. doi: 10.1016/j.hoc.2023.08.001 - DOI - PMC - PubMed
    1. National Academies of Sciences, Engineering, and Medicine; Policy and Global Affairs; Committee on Women in Science, Engineering, and Medicine; Committee on Improving the Representation of Women and Underrepresented Minorities in Clinical Trials and Research , Bibbins-Domingo K, Helman A, eds. Improving Representation in Clinical Trials and Research: Building Research Equity for Women and Underrepresented Groups. National Academies Press (US); 2022. - PubMed

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