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. 2024 May 7;13(1):107.
doi: 10.1038/s41377-024-01454-w.

A head-mounted photoacoustic fiberscope for hemodynamic imaging in mobile mice

Xiaoyan Zheng  1 , Shuai Na  2   3
Affiliations

A head-mounted photoacoustic fiberscope for hemodynamic imaging in mobile mice

Xiaoyan Zheng et al. Light Sci Appl. .

Abstract

A miniaturized photoacoustic fiberscope has been developed, featuring a lateral resolution of 9 microns and a lightweight design at 4.5 grams. Engineered to capture hemodynamic processes at single-blood-vessel resolution at a rate of 0.2 Hz, this device represents an advancement in head-mounted tools for exploring intricate brain activities in mobile animals.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Schematic diagram of the head-mounted photoacoustic fiberscope
Fig. 2
Fig. 2. Experimental results of the hypercapnia challenge.
a A freely moving mouse wearing the imaging probe; b sO2 changes in a hypercapnia-normocapnia cycle; c The corresponding changes in Hb levels
See this image and copyright information in PMC

References

    1. Raichle ME, Mintun MA. Brain work and brain imaging. Annu. Rev. Neurosci. 2006;29:449–476. doi: 10.1146/annurev.neuro.29.051605.112819. - DOI - PubMed
    1. Hall CN, et al. Oxidative phosphorylation, not glycolysis, powers presynaptic and postsynaptic mechanisms underlying brain information processing. J. Neurosci. 2012;32:8940–8951. doi: 10.1523/JNEUROSCI.0026-12.2012. - DOI - PMC - PubMed
    1. Yao JJ, et al. High-speed label-free functional photoacoustic microscopy of mouse brain in action. Nat. Methods. 2015;12:407–410. doi: 10.1038/nmeth.3336. - DOI - PMC - PubMed
    1. Yao JJ, Wang LV. Photoacoustic brain imaging: from microscopic to macroscopic scales. Neurophotonics. 2014;1:011003. doi: 10.1117/1.NPh.1.1.011003. - DOI - PMC - PubMed
    1. Danielli A, et al. Nonlinear photoacoustic spectroscopy of hemoglobin. Appl. Phys. Lett. 2015;106:203701. doi: 10.1063/1.4921474. - DOI - PMC - PubMed