Nuclear pseudoinclusions as a clue for NUTM1-rearranged poroid tumours recognition

Antoine Taillandier¹, Mélanie Legrand¹, Adrien Petereau¹, Anne Tallet², Christine Collin², Eric Frouin^{3

4}, Marie-Laure Jullie^{3

5}, Nicolas Macagno^{3

6

7}, Maxime Battistella^{3

8}, Thibault Kervarrec^{1

3

9}

Affiliations

¹ Department of Pathology, University Hospital of Tours, Tours, France.
² Platform of Solid Tumor Molecular Genetics, University Hospital Center of Tours, Tours, France.
³ CARADERM, French Network of Rare Cutaneous Cancer, France.
⁴ Department of Pathology, University Hospital of Nimes, University of Nimes, Nimes, France.
⁵ Department of Pathology, University Hospital of Bordeaux, Bordeaux, France.
⁶ Department of Pathology, APHM, Timone University Hospital, Marseille, France.
⁷ Aix-Marseille University, INSERM U1251, MMG, Marseille, France.
⁸ Department of Pathology, Hospital Saint-Louis, AP-HP, Université Paris Cité, INSERM U976, Paris, France.
⁹ Biologie des Infections à Polyomavirus Team, UMR1282 INRAE, University of Tours, Tours, France.

Case Reports

Antoine Taillandier et al. Histopathology. 2024 Aug.

. 2024 Aug;85(2):362-365.

doi: 10.1111/his.15208. Epub 2024 May 7.

¹ Department of Pathology, University Hospital of Tours, Tours, France.
² Platform of Solid Tumor Molecular Genetics, University Hospital Center of Tours, Tours, France.
³ CARADERM, French Network of Rare Cutaneous Cancer, France.
⁴ Department of Pathology, University Hospital of Nimes, University of Nimes, Nimes, France.
⁵ Department of Pathology, University Hospital of Bordeaux, Bordeaux, France.
⁶ Department of Pathology, APHM, Timone University Hospital, Marseille, France.
⁷ Aix-Marseille University, INSERM U1251, MMG, Marseille, France.
⁸ Department of Pathology, Hospital Saint-Louis, AP-HP, Université Paris Cité, INSERM U976, Paris, France.
⁹ Biologie des Infections à Polyomavirus Team, UMR1282 INRAE, University of Tours, Tours, France.

No abstract available

References

1. Kervarrec T, Pissaloux D, Tirode F et al. Gene fusions in poroma, porocarcinoma and related adnexal skin tumours: An update. Histopathology 2024; 84; 266–278.
1. Sekine S, Kiyono T, Ryo E et al. Recurrent YAP1‐MAML2 and YAP1‐NUTM1 fusions in poroma and porocarcinoma. J. Clin. Invest. 2019; 129; 3827–3832.
1. Macagno N, Kervarrec T, Sohier P et al. NUT is a specific immunohistochemical marker for the diagnosis of YAP1‐NUTM1‐rearranged cutaneous poroid neoplasms. Am. J. Surg. Pathol. 2021; 45; 1221–1227.
1. Kervarrec T, Pissaloux D, Paindavoine S et al. Recurrent PAK2 rearrangements in poroma with folliculo‐sebaceous differentiation. Histopathology 2023; 83; 310–319.
1. Kervarrec T, Frouin E, Collin C et al. Distinct regulations driving YAP1 expression loss in poroma, porocarcinoma and RB1‐deficient skin carcinoma. Histopathology 2023; 82; 885–898.