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Editorial
. 2024 Sep;71(3):259-261.
doi: 10.1165/rcmb.2024-0195ED.

Monocytes: See One Queuing Local Adaptive Immune Responses to Respiratory Viruses

Alexander P Earhart  1 , Hrishikesh S Kulkarni  1
Affiliations
Editorial

Monocytes: See One Queuing Local Adaptive Immune Responses to Respiratory Viruses

Alexander P Earhart et al. Am J Respir Cell Mol Biol. 2024 Sep.
No abstract available

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Figures

Figure 1.
Figure 1.
The C1q–C1qR axis is upregulated in respiratory viral infection. Infection with respiratory viruses such as human metapneumovirus results in lung inflammation, which upregulates C1q in iMono in the lung, while injury is ongoing. C1q binds to C1qR on CD8+ T cells, resulting in the upregulation of T-cell effector function, including production of granzyme B, IL-2, and IFN-γ, increasing the metabolic capacity of these cells and increasing their proliferation, subsequently resulting in viral clearance and limiting damage. This figure was created using www.biorender.com. iMono = inflammatory monocytes.
See this image and copyright information in PMC

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References

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