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Randomized Controlled Trial
. 2024 Aug 1;43(8):809-812.
doi: 10.1097/INF.0000000000004373. Epub 2024 May 8.

The Impact of Infant Bacille Calmette-Guérin Vaccination on the Immunogenicity of Other Vaccines: A Randomized Exploratory Study

Alexander Maytum  1 , David Porter  1 , Philip de Whalley  1 , Amber Thompson  1 , Emma Plested  1 , Simon Kerridge  1 , Xinxue Liu  1 , Gaby Smits  2 , Fiona van der Klis  2 , Matthew D Snape  1 , Elizabeth Clutterbuck  1 , Andrew J Pollard  1
Affiliations
Randomized Controlled Trial

The Impact of Infant Bacille Calmette-Guérin Vaccination on the Immunogenicity of Other Vaccines: A Randomized Exploratory Study

Alexander Maytum et al. Pediatr Infect Dis J. .

Abstract

The effect of the Bacille Calmette-Guérin (BCG) vaccine on the immunogenicity of separately administered serogroup C meningococcal vaccine and other vaccinations was examined in 28 infants randomized to receive BCG at age ≤7 days, at 3 months or after study completion. Immunogenicity of the serogroup C meningococcal vaccine and other routine vaccines might be improved when BCG is administered in early infancy.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

References

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