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. 1985 Feb 1;161(2):423-8.
doi: 10.1084/jem.161.2.423.

Induction of severe autoimmune disease in normal mice by simultaneous action of multiple immunostimulators

L M Hang, M T Aguado, F J Dixon, A N Theofilopoulos

Induction of severe autoimmune disease in normal mice by simultaneous action of multiple immunostimulators

L M Hang et al. J Exp Med. .

Abstract

Either of two immunostimulating factors (lpr, lipopolysaccharide) enhanced the pathogenic autoimmune responses of MRL/n mice, but the serologic and immunopathologic characteristics differed. In contrast, either factor acting alone, caused minimal immunopathology in normal mice, despite autoantibody induction. Combined immunostimulation, however, caused fatal glomerulonephritis in normal-background C57BL/6 mice. These results show the profound influence of the background genome on the effects of immunostimulating agents, and show that resistance to autoimmune disease in immunologically normal mice is not absolute.

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