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Review
. 2024 Jun;1871(5):119746.
doi: 10.1016/j.bbamcr.2024.119746. Epub 2024 May 6.

Genetic dissection of the bacterial Fe-S protein biogenesis machineries

Mathieu Sourice  1 , Charlotte Oriol  1 , Corinne Aubert  1 , Pierre Mandin  1 , Béatrice Py  2
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Free article
Review

Genetic dissection of the bacterial Fe-S protein biogenesis machineries

Mathieu Sourice et al. Biochim Biophys Acta Mol Cell Res. 2024 Jun.
Free article

Abstract

Iron‑sulfur (Fe-S) clusters are one of the most ancient and versatile inorganic cofactors present in the three domains of life. Fe-S clusters are essential cofactors for the activity of a large variety of metalloproteins that play crucial physiological roles. Fe-S protein biogenesis is a complex process that starts with the acquisition of the elements (iron and sulfur atoms) and their assembly into an Fe-S cluster that is subsequently inserted into the target proteins. The Fe-S protein biogenesis is ensured by multiproteic systems conserved across all domains of life. Here, we provide an overview on how bacterial genetics approaches have permitted to reveal and dissect the Fe-S protein biogenesis process in vivo.

Keywords: Bacterial genetics; ISC; MIS; NIF; SMS; SUF.

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Conflict of interest statement

Declaration of competing interest Py reports financial support was provided by French National Research Agency. Mandin reports financial support was provided by French National Research Agency. Sourice reports financial support was provided by IM2B. Sourice reports financial support was provided by Foundation for Medical Research. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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