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. 2024 May;33(5):e5812.
doi: 10.1002/pds.5812.

The impact of hospitalization on inappropriate prescribing and polypharmacy in older patients: A descriptive cross-sectional study

Ori Weiss  1 , Andy Eyre  1   2 , Danny Alon Ellenbogen  3 , Gideon Y Stein  1   4
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The impact of hospitalization on inappropriate prescribing and polypharmacy in older patients: A descriptive cross-sectional study

Ori Weiss et al. Pharmacoepidemiol Drug Saf. 2024 May.

Abstract

Background: Polypharmacy and the use of potentially inappropriate medications (PIMs) in older individuals are widespread phenomena that are associated with an increase in morbidity and mortality. The Beers Criteria is a tool that helps to identify patients that are prescribed with PIMs, thereby reducing the risk of associated harm. Amongst other populations, the criteria identify drugs that should not be used by the majority of older patients.

Aim: Determining the proportion of older inpatients who were discharged from hospitalization with polypharmacy (a prescription for more than seven drugs), or with a PIM as defined by the Beers Criteria.

Methods: A descriptive cross-sectional study based on patients aged 65 and over who were hospitalized in the years 2019-2021 in the internal medicine, orthopedic and surgical wards at a medium-size hospital. Demographic information and details about drug treatment were collected from the electronic patient records system. Patients who died during hospitalization were excluded from the study group.

Main outcome measures: The proportion of inpatients with polypharmacy or a PIM as part of their regular prescription, at the time of admission and at discharge.

Results: 49 564 patients were included in the study cohort. At discharge, 19% of the patients were given a prescription for a PIM, with a small but significant decrease compared with the rate admission (22.1%). At discharge, 42.8% of patients had polypharmacy, representing a small but significant increase compared with the rate on admission (40.6%).

Conclusions: The study demonstrated high baseline rates of PIM prescription and polypharmacy. Hospitalization was associated with a decrease in PIM prescription and an increase in polypharmacy. This highlights the importance of medication review during admission to reduce the potential risk to older adults from polypharmacy and PIM prescription.

Keywords: Beers Criteria; PIM; polypharmacy; potentially inappropriate medications.

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References

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