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Review
. 2024 Apr 24:14:1362436.
doi: 10.3389/fonc.2024.1362436. eCollection 2024.

Knowledge mapping and research trends of exosomes in pancreatic cancer: a bibliometric analysis and review (2013-2023)

Yongjiang Zhou  1   2 , Jiajie Feng  1   2 , Qingqing Wang  1 , Yiwen Zhao  1   2 , Hanyu Ding  1   3 , Kexin Jiang  1   3 , Hua Ji  1   2 , Zheng Tang  1   2 , Ruiwu Dai  1   2   3   4
Affiliations
Review

Knowledge mapping and research trends of exosomes in pancreatic cancer: a bibliometric analysis and review (2013-2023)

Yongjiang Zhou et al. Front Oncol. .

Abstract

Objective: This review aims to provide a quantitative and qualitative bibliometric analysis of literature from 2013 to 2023 on the role of exosomes in PC, with the goal of identifying current trends and predicting future hotspots.

Methods: We retrieved relevant publications concerning exosomes in PC, published between 2013 and 2023, from the Web of Science Core Collection. Bibliometric analyses were conducted using VOSviewer(1.6.19), CiteSpace(6.2.R4), and Microsoft Excel (2019).

Results: A total of 624 papers were analyzed, authored by 4017 researchers from 55 countries/regions and 855 institutions, published in 258 academic journals. China (n=285, 34.42%) and the United States (n=183, 24.87%) were the most frequent contributors and collaborated closely. However, publications from China had a relatively low average number of citations (41.45 times per paper). The output of Shanghai Jiao Tong University ranked first, with 28 papers (accounting for 4.5% of the total publications). Cancers (n=31, 4.9%); published the most papers in this field. Researcher Margot Zoeller published the most papers (n=12) on this topic. Research hotspots mainly focused on the mechanisms of exosomes in PC onset and progression, the role of exosomes in PC early diagnosis and prognosis, exosomes promote the development of PC chemoresistance, and potential applications of exosomes as drug carriers for PC therapies. We observed a shift in research trends, from mechanistic studies toward clinical trials, suggesting that clinical applications will be the focus of future attention. Emerging topics were pancreatic stellate cells, diagnostic biomarkers, mesenchymal stem cells, extracellular vesicles.

Conclusion: Our scientometric and visual analysis provides a comprehensive overview of the literature on the role of exosomes in PC published during 2013-2023. This review identifies the frontiers and future directions in this area over the past decade, and is expected to provide a useful reference for researchers in this field.

Keywords: CiteSpace; VOS viewer; bibliometric study; exosomes; pancreatic cancer; research hotspots.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flow diagram of the search strategy and analysis for research on exosomes in pancreatic cancer.
Figure 2
Figure 2
The number of annual research publications and growth trends on exosomes in pancreatic cancer from 2013 to 2023.
Figure 3
Figure 3
Articles related to the exosomes in pancreatic cancer published by country/region and institutions. (A) Collaboration between countries/regions based on https://bibliometric.com. (B) The publications density map of country/region. (C) Collaboration networks between institutions drawn by VOSviewer.
Figure 4
Figure 4
The co-authorship network analysis of authors. The size of the circle represents the number of publications; the thickness of the line represent collaborations between authors; the circle colors represents different clusters.
Figure 5
Figure 5
Journals related to exosomes in pancreatic cancer. (A) The overlay visualization map of journals associated with research on exosomes in pancreatic cancer. The circle size means the number of publications; the circle colors mean the average published year. (B) The dual-map overlay of journals related to the exosomes in pancreatic cancer.
Figure 6
Figure 6
References related to the exosomes in pancreatic cancer. (A) Clustering analysis of the exosomes in pancreatic cancer cocitation network drawn by CiteSpace. (B) Cluster view of co-citation references related to exosomes in pancreatic cancer visualized by CiteSpace. (C) The top 25 with the strongest citation bursts based on analysis in CiteSpace.
Figure 7
Figure 7
Keywords related to exosomes in pancreatic cancer. (A) Network visualization of keywords drawn by VOSviewer. The circle size means the keywords frequency of occurrence; the circle colors mean different clusters; (B) Overlay visualization of keywords drawn by VOSviewer. The circle size means the keywords frequency of occurrence; the circle colors mean the average published year. (C) The top 25 keywords with the strongest citation bursts drawn by CiteSpace. A red bar indicates high citations in that year.
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