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Review
. 2024 Apr 24:12:1384591.
doi: 10.3389/fped.2024.1384591. eCollection 2024.

Unraveling chronic kidney disease in children: a surprising manifestation of celiac disease

Iuliana Magdalena Starcea #  1 , Ingrith Miron #  1 , Ancuta Lupu #  1 , Ileana Ioniuc #  1 , Mirabela Alecsa #  1 , Alice Azoicai #  1 , Ionela Daniela Morariu #  2 , Valentin Munteanu #  3 , Vasile Valeriu Lupu #  1 , Adriana Mocanu #  1
Affiliations
Review

Unraveling chronic kidney disease in children: a surprising manifestation of celiac disease

Iuliana Magdalena Starcea et al. Front Pediatr. .

Abstract

Celiac disease, firstly described in children, is a type of T-cell enteropathy that occurs in individuals genetically predisposed to gluten exposure. The estimated global prevalence of celiac disease is continuously increasing. Although, traditionally, celiac disease was diagnosed in children with failure to thrive and digestive issues, it is now recognized that may present with a wide range of symptoms beyond gastrointestinal ones. Celiac disease continues to pose significant challenges due to the continuous advancement of knowledge in understanding its pathophysiology, diagnosing the condition, managing its effects, and exploring potential therapeutic approaches. The prevalence of celiac disease is increased among individuals with chronic kidney disease, also. The most frequent associations are with diabetic nephropathy, IgA nephropathy and urolithiasis. A gut-kidney axis has been recognized to play a significant role in chronic kidney diseases. This literature review aims to review the chronic renal pathology associated with celiac disease, with emphasis on childhood.

Keywords: IgA nephropathy; celiac disease; children; chronic kidney disease; diabetic nephropathy.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Pathogeny of IgA nephropathy in celiac disease.
Figure 2
Figure 2
Implication of celiac disease in chronic kidney disease.
See this image and copyright information in PMC

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