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. 1985 Feb;59(2):398-404.

Immunoregulatory effects of interferon-alpha. I. Interferon-alpha inhibits in vitro antibody synthesis by normal human lymphocytes

B K Pelton, A M Denman

Immunoregulatory effects of interferon-alpha. I. Interferon-alpha inhibits in vitro antibody synthesis by normal human lymphocytes

B K Pelton et al. Clin Exp Immunol. 1985 Feb.

Abstract

The effects of human interferon-alpha (IFN-alpha) on in vitro synthesis of specific anti-influenza virus antibody were measured in cultures of peripheral blood lymphocytes from normal donors. IFN-alpha suppressed antibody synthesis in a time and dose related manner. This suppression was also produced by monoclonal antibody purified IFN-alpha and was blocked by anti-IFN-alpha antibody. However antibody induced by a combination of antigen and 'B cell helper supernatant' was not suppressed indicating that IFN-alpha inhibits the initial events in antibody synthesis but does not affect cells committed to antibody production.

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References

    1. Biochim Biophys Acta. 1978 Oct 27;516(2):231-47 - PubMed
    1. Cell Immunol. 1978 Oct;40(2):285-93 - PubMed
    1. N Engl J Med. 1979 Jul 5;301(1):5-8 - PubMed
    1. Nature. 1979 Nov 22;282(5737):417-9 - PubMed
    1. Nature. 1979 Dec 13;282(5740):734-6 - PubMed

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