Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1985 Apr;48(1):248-51.
doi: 10.1128/iai.48.1.248-251.1985.

Haemophilus influenzae can use human transferrin as a sole source for required iron

D A Herrington, P F Sparling

Haemophilus influenzae can use human transferrin as a sole source for required iron

D A Herrington et al. Infect Immun. 1985 Apr.

Abstract

Haemophilus influenzae grown on enriched medium containing protoporphyrin IX rather than hemin was iron starved by the addition of the chelator ethylenediamine di-o-hydroxyphenylacetic acid. Iron starvation could be overcome in each of 33 H. influenzae type b isolates by 30% Fe-saturated human transferrin but not by human lactoferrin. Among nontypeable H. influenzae, 28 of 35 isolates, including 2 of 3 systemic isolates, were able to utilize Fe-transferrin. None of 18 H. parainfluenzae isolates was able to use Fe-transferrin. Iron starvation of H. influenzae type b resulted in increased amounts of three membrane proteins of 94,000 to 98,000 daltons.

PubMed Disclaimer

References

    1. Nature. 1970 Aug 15;227(5259):680-5 - PubMed
    1. J Exp Med. 1969 Sep 1;130(3):643-58 - PubMed
    1. J Biol Chem. 1971 Jan 10;246(1):69-73 - PubMed
    1. J Med Microbiol. 1975 Nov;8(4):477-90 - PubMed
    1. J Lab Clin Med. 1976 Sep;88(3):477-86 - PubMed

Publication types