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. 1985 Feb;47(2):181-9.
doi: 10.1080/09553008514550251.

Role of chromatin structure in the repair of DNA photoproducts in mammalian cells

R S Nairn, D L Mitchell, J M Clarkson

Role of chromatin structure in the repair of DNA photoproducts in mammalian cells

R S Nairn et al. Int J Radiat Biol Relat Stud Phys Chem Med. 1985 Feb.

Abstract

Chinese hamster ovary cells were irradiated with u.v. light and chromatin was isolated and fractionated according to magnesium-solubility in low ionic strength conditions. The minor, magnesium-soluble chromatin fraction was demonstrated to be enriched by over three-fold in transcriptionally active sequences and had proteins associated with it characteristic of transcriptionally active chromatin. Using a sensitive radioimmunoassay for u.v.-induced DNA photoproducts, we have shown that there are no differences in either induction or repair of u.v. DNA photoproducts in chromatin fractions from cells irradiated at low u.v. fluence.

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