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. 2024 Jul:264:110237.
doi: 10.1016/j.clim.2024.110237. Epub 2024 May 8.

Proteomic mapping identifies serum marker signatures associated with MIS-C specific hyperinflammation and cardiovascular manifestation

Andrea Reiter  1 , Emely L Verweyen  1 , Emmanuelle Queste  2 , Sabrina Fuehner  1 , André Jakob  3 , Katja Masjosthusmann  4 , Claas Hinze  1 , Helmut Wittkowski  1 , Dirk Foell  1 , Ulrich Meinzer  2 , Isabelle Melki  5 , Christoph Kessel  6 ; MIS-C Robert-Debré consortium
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Free article

Proteomic mapping identifies serum marker signatures associated with MIS-C specific hyperinflammation and cardiovascular manifestation

Andrea Reiter et al. Clin Immunol. 2024 Jul.
Free article

Abstract

Multisystem inflammatory syndrome in children (MIS-C) shares several clinical and immunological features with Kawasaki Disease (KD) and pediatric hyperinflammation, but the immuno-phenotypic overlap among these clinical mimics is still incompletely understood. Here we analyzed serum samples from treatment-naïve patients with MIS-C (n = 31) and KD (n = 11), pediatric hyperinflammation (n = 13) and healthy controls (HC, n = 10) by proximity extension assay (PEA) to profile 184 blood biomarkers. Collectively, immunophenotypic overlap between MIS-C and hyperinflammation exceeds overlap with KD. Overexpression of IL-17A in MIS-C and KD could best separate these conditions from hyperinflammatory conditions, while those were hallmarked by overabundance of adenosin deaminase and IL-18. Depletion in serum TNF-related subfamily member 9 (TNFRSF9) and apoptosis inducing ligand (TRAIL) linked with cardiovascular manifestations and myocarditis in MIS-C. Altogether, our analysis highlights important differences in molecular marker signatures also across different MIS-C and KD cohorts and suggests several previously unidentified molecular associations in context of cardiovascular inflammation.

Keywords: Hyperinflammation; Kawasaki disease; Multisystem inflammatory syndrome in children (MIS-C); Proteomics.

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Conflict of interest statement

Declaration of competing interest CH has received honoraria (lecture fees) from Novartis; HW has received honoraria (lecture fees) from Novartis and Takeda, and travel support from Octapharma and CSL-Behring; DF received speaker fees/honoraria from Chugai-Roche, Novartis and SOBI as well as research support from Novartis, Pfizer and SOBI. CK has received consulting fees from Novartis and Swedish Orphan Biovitrum (SOBI) (< $10,000 each) and receives research support from Novartis (> $10,000). No other disclosures relevant to this article were reported.

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