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Case Reports
. 1985 Apr;78(4):488-9.
doi: 10.1097/00007611-198504000-00035.

Coagulopathy and hemorrhage associated with cefoperazone therapy in a patient with renal failure

T D Shenkenberg, P A Mackowiak, J W Smith
Case Reports

Coagulopathy and hemorrhage associated with cefoperazone therapy in a patient with renal failure

T D Shenkenberg et al. South Med J. 1985 Apr.

Abstract

We have reported life-threatening gastrointestinal hemorrhage with hypoprothrombinemia in a patient treated with cefoperazone for a urinary tract infection. The coagulation abnormality was rapidly corrected with administration of vitamin K and discontinuation of the antibiotic. This complication of cefoperazone therapy is not widely recognized and may be seen more frequently with increased use of the drug.

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