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. 2024 May 2;35(2):102191.
doi: 10.1016/j.omtn.2024.102191. eCollection 2024 Jun 11.

Trans-amplifying RNA hitting new grounds: Gene regulation by microRNA

Affiliations

Trans-amplifying RNA hitting new grounds: Gene regulation by microRNA

Kenneth Lundstrom. Mol Ther Nucleic Acids. .
No abstract available

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Conflict of interest statement

The author declares no competing interests.

References

    1. Beissert T., Perkovic M., Vogel A., Erbar S., Walzer K.C., Hempel T., Brill S., Haefner E., Becker R., Türeci Ö., Sahin U. A trans-amplifying RNA vaccine strategy for induction of potent protective immunity. Mol. Ther. 2020;28:119–128. doi: 10.1016/j.ymthe.2019.09.009. - DOI - PMC - PubMed
    1. Perkovic M., Gawletta S., Hempel T., Brill S., Nett E., Sahin U., Beissert T. A trans-amplifying RNA simplified to essential elements is highly replicative and robustly immunogenic in mice. Mol. Ther. 2023;31:1636–1646. doi: 10.1016/j.ymthe.2023.01.019. - DOI - PMC - PubMed
    1. Yıldız A., Hasani A., Hempel T., Köhl N., Beicht A., Becker R., Beissert T., Hubich-Rau S., Suchan M., Poleganov M.A., Sahin U. Trans-amplifying RNA expressing functional miRNA mediates target-specific gene suppression and simultaneous transgene expression. Mol. Ther. Nucleic Acids. 2024;35 doi: 10.1016/j.omtn.2024.102162. - DOI - PMC - PubMed
    1. Setten R.L., Rossi J.J., Han S.P. The current state and future directions of RNAi-based therapeutics. Nat. Rev. Drug Discov. 2019;18:421–446. - PubMed
    1. McBride J.L., Boudreau R.L., Harper S.Q., Staber P.D., Monteys A.M., Martins I., Gilmore B.L., Burstein H., Peluso R.W., Polisky B., et al. Artificial miRNAs mitigate shRNA-mediated toxicity in the brain: Implications for the therapeutic development of RNAi. Proc. Natl. Acad. Sci. USA. 2008;105:5868–5873. - PMC - PubMed

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