Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 May;35(5):e14133.
doi: 10.1111/pai.14133.

Metabolomic pathways in food allergy

So-Yeon Lee  1 , Yoon Mee Park  2 , Hyun Ju Yoo  3 , Soo-Jong Hong  4
Affiliations
Review

Metabolomic pathways in food allergy

So-Yeon Lee et al. Pediatr Allergy Immunol. 2024 May.

Abstract

Food allergy (FA) is a widespread issue, affecting as many as 10% of the population. Over the past two to three decades, the prevalence of FA has been on the rise, particularly in industrialized and westernized countries. FA is a complex, multifactorial disease mediated by type 2 immune responses and involving environmental and genetic factors. However, the precise mechanisms remain inadequately understood. Metabolomics has the potential to identify disease endotypes, which could beneficially promote personalized prevention and treatment. A metabolome approach would facilitate the identification of surrogate metabolite markers reflecting the disease activity and prognosis. Here, we present a literature overview of recent metabolomic studies conducted on children with FA.

Keywords: children; food allergy; metabolomics.

PubMed Disclaimer

References

REFERENCES

    1. Berin MC, Sampson HA. Mucosal immunology of food allergy. Curr Biol. 2013;23(9):R389‐R400.
    1. Kalach N, Rocchiccioli F, de Boissieu D, Benhamou PH, Dupont C. Intestinal permeability in children: variation with age and reliability in the diagnosis of cow's milk allergy. Acta Paediatr. 2001;90(5):499‐504.
    1. Nwaru BI, Hickstein L, Panesar SS, et al. The epidemiology of food allergy in Europe: a systematic review and meta‐analysis. Allergy. 2014;69(1):62‐75.
    1. Bilaver LA, Chadha AS, Doshi P, O'Dwyer L, Gupta RS. Economic burden of food allergy: a systematic review. Ann Allergy Asthma Immunol. 2019;122(4):373‐380.
    1. Sicherer SH, Sampson HA. Food allergy: a review and update on epidemiology, pathogenesis, diagnosis, prevention, and management. J Allergy Clin Immunol. 2018;141(1):41‐58.

Publication types

Grants and funding

LinkOut - more resources