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Review
. 2024 May 10;103(19):e38088.
doi: 10.1097/MD.0000000000038088.

Mechanisms of microbiota modulation: Implications for health, disease, and therapeutic interventions

Okechukwu Paul-Chima Ugwu  1 , Esther Ugo Alum, Michael Ben Okon, Emmanuel I Obeagu
Affiliations
Review

Mechanisms of microbiota modulation: Implications for health, disease, and therapeutic interventions

Okechukwu Paul-Chima Ugwu et al. Medicine (Baltimore). .

Abstract

Microbiota modulation, the intentional change in the structure and function of the microbial community, is an emerging trajectory that holds the promise to mitigate an infinite number of health issues. The present review illustrates the underlying principles of microbiota modulation and the various applications of this fundamental process to human health, healthcare management, and pharmacologic interventions. Different strategies, directing on dietary interventions, fecal microbiota transplantation, treatment with antibiotics, bacteriophages, microbiome engineering, and modulation of the immune system, are described in detail. This therapeutic implication is reflected in clinical applications to gastrointestinal disorders and immune-mediated diseases for microbiota-modulating agents. In addition to this, the review outlines the challenges of translating researched outcomes into clinical practice to consider safety and provides insights into future research directions of this rapidly developing area.

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Conflict of interest statement

The authors have no funding and conflicts of interest to disclose.

Figures

Figure 1.
Figure 1.
Benefits of microbiota modulation
Figure 2.
Figure 2.
Mechanisms of microbiota modulation
Figure 3.
Figure 3.
The role of microbiota modulation in preventing and treatment of infectious diseases.
See this image and copyright information in PMC

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