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Multicenter Study
. 2024 Jun:54:102081.
doi: 10.1016/j.suronc.2024.102081. Epub 2024 Apr 26.

The pan - COVID - AGICT study. The impact of COVID-19 pandemic on surgically treated pancreatic cancer patients. A multicentric Italian study

Maria Pia Federica Dorma  1 , Giuseppe Giuliani  2 , Francesco Guerra  2 , Francesco Santelli  3 , Alessandro Esposito  4 , Matteo De Pastena  4 , Giulia Turri  5 , Corrado Pedrazzani  5 , Emanuele Federico Kauffmann  6 , Ugo Boggi  6 , Leonardo Solaini  7 , Giorgio Ercolani  7 , Laura Mastrangelo  8 , Elio Jovine  8 , Gregorio Di Franco  9 , Luca Morelli  9 , Michele Mazzola  10 , Giovanni Ferrari  10 , Serena Langella  11 , Alessandro Ferrero  11 , Roberta La Mendola  12 , Mohamnad Abu Hilal  12 , Norma Depalma  13 , Stefano D'Ugo  13 , Marcello Giuseppe Spampinato  13 , Marco Frisini  14 , Alberto Brolese  14 , Raffaele Palaia  15 , Andrea Belli  15 , Nicola Cillara  16 , Antonello Deserra  16 , Alessandro Cannavera  16 , Andrea Sagnotta  17 , Stefano Mancini  17 , Enrico Pinotti  18 , Mauro Montuori  18 , Alessandro Coppola  19 , Fabrizio Di Benedetto  20 , Andrea Coratti  2 ; COVID-AGICT Collaborative Group
Collaborators, Affiliations
Free article
Multicenter Study

The pan - COVID - AGICT study. The impact of COVID-19 pandemic on surgically treated pancreatic cancer patients. A multicentric Italian study

Maria Pia Federica Dorma et al. Surg Oncol. 2024 Jun.
Free article

Abstract

Background: In this article we aimed to perform a subgroup analysis using data from the COVID-AGICT study, to investigate the perioperative outcomes of patients undergoing surgery for pancreatic cancers (PC) during the COVID-19 pandemic.

Methods: The primary endpoint of the study was to find out any difference in the tumoral stage of surgically treated PC patients between 2019 and 2020. Surgical and oncological outcomes of the entire cohort of patients were also appraised dividing the entire peri-pandemic period into six three-month timeframes to balance out the comparison between 2019 and 2020.

Results: Overall, a total of 1815 patients were surgically treated during 2019 and 2020 in 14 Italian surgical Units. In 2020, the rate of patients treated with an advanced pathological stage was not different compared to 2019 (p = 0.846). During the pandemic, neoadjuvant chemotherapy (NCT) has dropped significantly (6.2% vs 21.4%, p < 0.001) and, for patients who didn't undergo NCT, the latency between diagnosis and surgery was shortened (49.58 ± 37 days vs 77.40 ± 83 days, p < 0.001). During 2020 there was a significant increase in minimally invasive procedures (p < 0.001). The rate of postoperative complication was the same in the two years but during 2020 there was an increase of the medical ones (19% vs 16.1%, p = 0.001).

Conclusions: The post-pandemic dramatic modifications in healthcare provision, in Italy, did not significantly impair the clinical history of PC patients receiving surgical resection. The present study is one of the largest reports available on the argument and may provide the basis for long-term analyses.

Keywords: COVID-19 pandemic; Pancreatic cancer; Pancreatic ductal adenocarcinoma; SARS-CoV2; Surgery.

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