doi: 10.1084/jem.161.5.1225.
Interleukin 2-induced proliferation of leukemic human B cells
- PMID: 3872922
- PMCID: PMC2187614
- DOI: 10.1084/jem.161.5.1225
Item in Clipboard
Interleukin 2-induced proliferation of leukemic human B cells
J Exp Med.
.
Abstract
The proliferative responses of purified leukemic human B cells from nine B cell chronic lymphocytic leukemias to recombinant interleukin 2 (IL-2), spontaneously, and after preactivation by Staphylococcus aureus Cowan I (SAC) or anti-mu antibodies were studied. Three patterns of response were observed: (a) no response (three cases); (b) a moderate spontaneous response enhanced by anti-mu (one case); (c) a high proliferative response after preactivation by anti-mu and/or SAC (five cases). IL-2 could also trigger normal B cells, purified from spleen, to proliferative after preactivation by anti-mu or SAC. These results provide evidence that IL-2 is a lymphokine that acts physiologically on both B and T cells.
Similar articles
-
Different reactivity of activated human B cells to B-cell growth factor and interleukin 2 in the costimulation assay with anti-IgM antibody and in the preactivation assay with Staphylococcus bacteria.Cell Immunol. 1985 Oct 15;95(2):358-67. doi: 10.1016/0008-8749(85)90323-5. Cell Immunol. 1985. PMID: 3876163
-
Surface immunoglobulins are involved in the interaction of protein A with human B cells and in the triggering of B cell proliferation induced by protein A-containing Staphylococcus aureus.J Immunol. 1981 Oct;127(4):1307-13. J Immunol. 1981. PMID: 6974188
-
Proliferation of leukemic B cells in response to SAC and anti-mu. Evidence for different modes of action and comparison to proliferation and differentiation induced by conditioned medium.Leuk Res. 1988;12(7):559-66. doi: 10.1016/0145-2126(88)90085-9. Leuk Res. 1988. PMID: 3262791
-
Regulatory effects of IL-4 on human B-cell response to IL-2.Eur Cytokine Netw. 1990 May-Jun;1(2):57-64. Eur Cytokine Netw. 1990. PMID: 2102812 Review.
-
From the point of view of the B cell: considerations on B-cell activation.Scand J Immunol. 1985 Sep;22(3):235-43. doi: 10.1111/j.1365-3083.1985.tb01876.x. Scand J Immunol. 1985. PMID: 3901245 Review. No abstract available.
Cited by
-
Demonstration of high-affinity interleukin-2 receptors on B-chronic lymphocytic leukemia cells: functional and structural characterization.Blut. 1990 Mar;60(3):181-6. doi: 10.1007/BF01720273. Blut. 1990. PMID: 2180499
-
Activation of B chronic lymphocytic leukaemia cells by Branhamella catarrhalis.Immunology. 1987 Jan;60(1):45-50. Immunology. 1987. PMID: 3493206 Free PMC article.
-
Mechanisms of physiologic B cell responses and B cell hyperactivity in systemic lupus erythematosus.Springer Semin Immunopathol. 1986;9(2-3):195-218. doi: 10.1007/BF02099022. Springer Semin Immunopathol. 1986. PMID: 2949381 Review. No abstract available.
-
Growth and survival of B-chronic lymphocytic leukaemia cells.Med Oncol. 1998 Jul;15(2):73-8. doi: 10.1007/BF02989583. Med Oncol. 1998. PMID: 9789213 Review.
-
Interleukin 10 (IL-10) upregulates functional high affinity IL-2 receptors on normal and leukemic B lymphocytes.J Exp Med. 1993 Nov 1;178(5):1473-81. doi: 10.1084/jem.178.5.1473. J Exp Med. 1993. PMID: 8228801 Free PMC article.
References
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials
