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Comment
. 2024 Jun;23(6):418.
doi: 10.1038/d41573-024-00082-8.

New route to target RAS

M Teresa Villanueva
Comment

New route to target RAS

M Teresa Villanueva. Nat Rev Drug Discov. 2024 Jun.
No abstract available

Keywords: Cancer; Chemistry; Drug discovery; Medical research.

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Comment on

  • Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy.
    Holderfield M, Lee BJ, Jiang J, Tomlinson A, Seamon KJ, Mira A, Patrucco E, Goodhart G, Dilly J, Gindin Y, Dinglasan N, Wang Y, Lai LP, Cai S, Jiang L, Nasholm N, Shifrin N, Blaj C, Shah H, Evans JW, Montazer N, Lai O, Shi J, Ahler E, Quintana E, Chang S, Salvador A, Marquez A, Cregg J, Liu Y, Milin A, Chen A, Ziv TB, Parsons D, Knox JE, Klomp JE, Roth J, Rees M, Ronan M, Cuevas-Navarro A, Hu F, Lito P, Santamaria D, Aguirre AJ, Waters AM, Der CJ, Ambrogio C, Wang Z, Gill AL, Koltun ES, Smith JAM, Wildes D, Singh M. Holderfield M, et al. Nature. 2024 May;629(8013):919-926. doi: 10.1038/s41586-024-07205-6. Epub 2024 Apr 8. Nature. 2024. PMID: 38589574 Free PMC article.

References

    1. Holderfield, M. et al. Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy. Nature https://doi.org/10.1038/s41586-024-07205-6 (2024)
    1. Wasko, U. N. et al. Tumor-selective activity of RAS-GTP inhibition in pancreatic cancer. Nature https://doi.org/10.1038/s41586-024-07379-z (2024)

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