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. 2024 Apr 25;13(9):2524.
doi: 10.3390/jcm13092524.

Gender Differences in Patients with Gastric Adenocarcinoma

Yujin Xing  1 , Hiroko Hosaka  1 , Fumitaka Moki  2 , Shota Tomaru  1 , Yuki Itoi  1 , Keigo Sato  1 , Yu Hashimoto  1 , Hirohito Tanaka  1 , Shiko Kuribayashi  1 , Yoji Takeuchi  1 , Kazue Nagai  3 , Toshio Uraoka  1
Affiliations

Gender Differences in Patients with Gastric Adenocarcinoma

Yujin Xing et al. J Clin Med. .

Abstract

Background: Gastric cancer (GC) epidemiology and outcomes vary by gender. Methods: We reviewed 18,436 GC patients from 2008 to 2018 and looked for gender differences in clinical characteristics and survival. Results: The gender proportion was 71% male and 29% female. Males had a significantly (p < 0.001) higher proportion of differentiated GC (66.3%) and a lower proportion of undifferentiated GC (26.3%). Diagnosis through medical check-ups was more common in males (30.0% vs. 26.4%, p < 0.001). Clinical staging revealed 54.6% of males and 52.9% of females had localized disease without lymph node metastasis (LNM), while distant metastasis occurred in 17.4% of males and 16.9% of females (p < 0.001). Kaplan-Meier survival curves indicated females had a significantly higher overall survival (p = 0.0018). The survival advantage for females was evident in the early stages, with a significant difference in localized disease without LNM (p < 0.001) and localized disease with LNM (p = 0.0026, log-rank test) but not in the advanced stages. Multivariate Cox regression analysis showed a significantly reduced mortality risk in females (p < 0.001). Conclusions: Significant gender differences exist with regard to pathological type, presentation, clinical stage, and overall survival. These findings suggest gender-specific strategies for screening, diagnosis, and treatment.

Keywords: adenocarcinoma; gastric cancer; gender differences; retrospective study.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
The number of the patients in each age group.
Figure 2
Figure 2
The pathological type in each age group.
Figure 2
Figure 2
The pathological type in each age group.
Figure 3
Figure 3
Kaplan–Meier survival curves for all patients. The dotted lines indicate MST (median survival time).
Figure 4
Figure 4
Kaplan–Meier survival curves for patients with different pathological classifications.
Figure 5
Figure 5
Kaplan–Meier survival curves for patients at different clinical stages.
Figure 6
Figure 6
Kaplan–Meier survival curves for patients in different age groups.
Figure 7
Figure 7
Hazard Ratios for mortality in gastric cancer by gender, age, pathology type, and clinical stage. ‘***’ indicates p < 0.001, which denotes a highly significant statistical difference.
See this image and copyright information in PMC

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