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. 2024 Apr 30;13(9):2640.
doi: 10.3390/jcm13092640.

Characterization of Perioperative Serotonin in Patients Undergoing Orthotopic Liver Transplantation

Tobias Zott  1   2 , David Pereyra  1   2 , Isabelle Kersten  1   3 , Max Ortner  1 , Maria Noelle Hüpper  1 , Patrick Starlinger  2   4 , Gabriela A Berlakovich  1 , Gerd R Silberhumer  1   2
Affiliations

Characterization of Perioperative Serotonin in Patients Undergoing Orthotopic Liver Transplantation

Tobias Zott et al. J Clin Med. .

Abstract

Background: Platelets were shown to be relevant for liver regeneration. In particular, platelet-stored serotonin (5-HT) proved to be a pro-regenerative factor in this process. The present study aimed to investigate the perioperative course of 5-HT and evaluate associations with patient and graft outcomes after othotopic liver transplantation (OLT). Methods: 5-HT was quantified in plasma and serum of 44 OLT recipients perioperatively, and in their respective donors. Olthoff's criteria for early allograft dysfunction (EAD) were used to evaluate postoperative outcomes. Results: Patients with higher donor intra-platelet 5-HT per platelet (IP 5-HT PP) values had significantly lower postoperative transaminases (ASAT POD1: p = 0.006, ASAT POD5: p = 0.006, ASAT POD10: p = 0.02, ALAT POD1: p = 0.034, ALAT POD5: p = 0.017, ALAT POD10: p = 0.04). No significant differences were seen between postoperative 5-HT values and the occurrence of EAD. A tendency was measured that donor IP 5-HT PP is lower in donor-recipient pairs that developed EAD (p = 0.07). Conclusions: Donor IP 5-HT PP might be linked to the postoperative development of EAD after OLT, as higher donor levels are correlated with a more favorable postoperative course of transaminases. Further studies with larger cohorts are needed to validate these findings.

Keywords: liver regeneration; liver transplantation; serotonin.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Timeline of blood sample acquisition. Two preoperative (donor and recipient) and three postoperative blood withdrawals on day one (POD 1), five (POD 5) and ten (POD 10).
Figure 2
Figure 2
Perioperative course of serum- (A), plasma- (B) and IP 5-HT (C) as well as IP 5-HT PP (D). Significant differences are highlighted. * p < 0.05. ** p < 0.005.
Figure 3
Figure 3
No significant differences in the recipients’ perioperative course of serum- (A), plasma- (B) and IP 5-HT (C) as well as IP 5-HT PP (D), each dichotomized by EAD.
Figure 4
Figure 4
Donor values of serum- (A), plasma- (B) and IP 5-HT (C) as well as IP 5-HT PP (D), each dichotomized by EAD. Moreover, the tendency of lower donor IP 5-HT PP in patients that later develop EAD can be seen in Subfigure D.
Figure 5
Figure 5
Comparison of liver parameters with our cohort dichotomized by median donor IP 5-HT PP. Platelet count (A), prothrombin ratio (B), bilirubin (C), GGT (D), ALAT (E) and ASAT (F) are shown. The significant differences in ASAT and ALAT are highlighted. * p < 0.05.
Figure 6
Figure 6
Scatter plots of donor IP 5-HT PP and donor values of GGT (A) and LDH (B) with.
See this image and copyright information in PMC

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