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Review
. 2024 May 2;29(9):2100.
doi: 10.3390/molecules29092100.

Research Progress in Pharmacological Effects and Mechanisms of Angelica sinensis against Cardiovascular and Cerebrovascular Diseases

Linlin Chen  1   2 , Bei Fan  2 , Fengzhong Wang  2 , Yang Song  1 , Xizhi Wang  1 , Ying Meng  1 , Yumin Chen  1 , Qing Xia  3 , Jing Sun  1
Affiliations
Review

Research Progress in Pharmacological Effects and Mechanisms of Angelica sinensis against Cardiovascular and Cerebrovascular Diseases

Linlin Chen et al. Molecules. .

Abstract

Angelica sinensis (Oliv.) Diels (A. sinensis) is a medicinal and edible values substance, which could promote blood circulation and enrich blood. It possesses rich chemical components and nutrients, which have significant therapeutic effects on cardiovascular and cerebrovascular diseases. It is commonly used for the prevention and treatment of cardiovascular and cerebrovascular diseases in the elderly, especially in improving ischemic damage to the heart and brain, protecting vascular cells, and regulating inflammatory reactions. This article reviews the main pharmacological effects and clinical research of A. sinensis on cardiovascular and cerebrovascular diseases in recent years, explores the effect of its chemical components on cardiovascular and cerebrovascular diseases by regulating the expression of functional proteins and inhibiting inflammation, anti-apoptosis, and antioxidant mechanisms. It provides a reference for further research on A. sinensis and the development of related drugs. It provides a new reference direction for the in-depth research and application of A. sinensis in the prevention, improvement, and treatment of cardiovascular and cerebrovascular diseases.

Keywords: Angelica sinensis; cardiovascular and cerebrovascular diseases; medicinal and edible values; polysaccharide; volatile oil.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The main chemical constituents of A. sinensis and their representative compounds.
Figure 2
Figure 2
Mechanisms of A. sinensis and its compounds in the treatment of cardiovascular diseases.
Figure 3
Figure 3
Mechanisms of A. sinensis and its compounds in the treatment of cerebrovascular diseases.
Figure 4
Figure 4
Mechanisms of A. sinensis and its compounds in the treatment of other vascular diseases.
See this image and copyright information in PMC

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