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Review
. 2024 Apr 23;14(9):861.
doi: 10.3390/diagnostics14090861.

The Importance of Microbiota and Fecal Microbiota Transplantation in Pancreatic Disorders

Adrian Boicean  1 , Cristian Ichim  1 , Samuel Bogdan Todor  1 , Paula Anderco  1 , Mirela Livia Popa  1
Affiliations
Review

The Importance of Microbiota and Fecal Microbiota Transplantation in Pancreatic Disorders

Adrian Boicean et al. Diagnostics (Basel). .

Abstract

The role of the intestinal microbiota in the diagnosis and treatment of pancreatic diseases is increasingly significant. Consequently, fecal microbiota transplantation (FMT) is emerging as a promising therapeutic avenue for various pancreatic disorders, including cancer, pancreatitis, and type 1 diabetes (T1D). This innovative procedure entails transferring gut microbiota from healthy donors to individuals affected by pancreatic ailments with the potential to restore intestinal balance and alleviate associated symptoms. FMT represents a pioneering approach to improve patient outcomes in pancreatic diseases, offering tailored treatments customized to individual microbiomes and specific conditions. Recent research highlights the therapeutic benefits of targeting the gut microbiota for personalized interventions in pancreatic disorders. However, a comprehensive understanding of the intricate interplay between gut microbiota and pancreatic physiology warrants further investigation. The necessity for additional studies and research endeavors remains crucial, especially in elucidating both adult and pediatric cases affected by pathological pancreatic conditions.

Keywords: T1D; fecal microbiota transplantation; microbiota; pancreatic cancer; pancreatitis.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Necessary steps for preparing the stool for microbiota transfer.
Figure 2
Figure 2
Fecal microbiota transplantation in pancreatic disorders.
See this image and copyright information in PMC

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