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. 2024 Apr 25;16(9):1275.
doi: 10.3390/nu16091275.

Increased Depressive-like, Anxiety-like, and Perseverative-like Behavior in Binge Eating Model in Juvenile Rats

Alma Delia Genis-Mendoza  1 , Isela Esther Juárez-Rojop  2 , Yudy Merady Escobar-Chan  2 , Carlos Alfonso Tovilla-Zárate  3 , María Lilia López-Narváez  3 , Humberto Nicolini  1 , Thelma Beatriz González-Castro  4
Affiliations

Increased Depressive-like, Anxiety-like, and Perseverative-like Behavior in Binge Eating Model in Juvenile Rats

Alma Delia Genis-Mendoza et al. Nutrients. .

Abstract

The aim of the present study was to evaluate depressive-like, anxiety-like, and perseverative-like behaviors in a binge eating model. Juvenile Wistar rats, using the binge eating model, were compared to caloric restriction, induced stress, and control groups. Rats of the induced stress group presented binge-like behaviors in standard food intake in the second cycle of the experiment when compared to the caloric restriction group and the binge eating model group. Depressive-like behavior was observed in the binge eating model group with longer immobility time (p < 0.001) and less swim time (p < 0.001) in comparison to the control group. Anxiety-like behavior was observed by shorter duration of burying latency in the binge eating model group when compared to the induced stress group (p = 0.04) and a longer duration of burying time when compared to the control group (p = 0.02). We observed perseverative-like behavior by the binge model group, who made more entries to the new arm (p = 0.0004) and spent a longer time in the new arm when compared to the control group (p = 0.0001). Our results show differences in behaviors between the groups of rats studied. These results suggest that calorie restriction-refeeding, along with stress, may lead to depressive-like, anxiety-like, and perseverative-like behavioral changes in male Wistar rats.

Keywords: animal model; anxiety-like; binge-like eating; depressive-like; perseverative-like.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Flow diagram showing the different phases of the experiment. During the second phase, the restriction was of standard food (pellets), and the refeeding was with HPF (Highly Palatable Food).
Figure 2
Figure 2
(A) Pellet Intake. Variations of standard food intake (in grams) of the four groups of rats during the three cycles of the experiment. Binge eating occurred in the group of stressed rats in the second cycle. Binge-like eating occurred in the induced stress group in the second cycle. The graph shows the grams of pellets provided to the caloric restriction groups (caloric restriction group and binge eating model group) during each cycle. (B) Highly palatable food intake (in grams) of the four groups of rats, during the three cycles of caloric restriction–refeeding. (C) Body weight variations (in grams) of the four groups of rats, during the three cycles of caloric restriction–refeeding. * p < 0.05.
Figure 3
Figure 3
Depressive-like behavior. (A) Immobility time (in seconds) of the four groups of rats. (B) Swimming time (in seconds) of the four groups of rats. (C) Climbing time (in seconds) of the four groups of rats. * p < 0.05, ** p < 0.01, *** p < 0.001.
Figure 4
Figure 4
Anxiety-like behavior. (A) Burial latency time (in seconds) of the four groups of rats. (B). Burial time (in seconds) of the four groups of rats. * p < 0.05.
Figure 5
Figure 5
Perseverative-like behavior. (A) Number of entries to the new arm (in percentage) of the four groups of rats during the first 2 min of the test. (B) Time spent in the new arm (in percentage) of the four groups of rats during the first 2 min of the test. * p < 0.05.
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