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Observational Study
. 2024 Apr 26;16(9):1292.
doi: 10.3390/nu16091292.

Association of Standardized Parenteral Nutrition with Early Neonatal Growth of Moderately Preterm Infants: A Population-Based Cohort Study

Laurence Fayol  1   2 , Jilnar Yaacoub  1 , Marine Baillat  1 , Clotilde des Robert  1 , Vanessa Pauly  3 , Gina Dagau  4 , Julie Berbis  3 , Frédérique Arnaud  5 , Audrey Baudesson  6 , Véronique Brévaut-Malaty  7 , Justine Derain-Court  8 , Blandine Desse  9 , Clara Fortier  10 , Eric Mallet  11 , Anaïs Ledoyen  12 , Christelle Parache  13 , Jean-Claude Picaud  14 , Philippe Quetin  15 , Bénédicte Richard  16 , Anne-Marie Zoccarato  17 , Anne-Marie Maillotte  2   18 , Farid Boubred  1   19
Affiliations
Observational Study

Association of Standardized Parenteral Nutrition with Early Neonatal Growth of Moderately Preterm Infants: A Population-Based Cohort Study

Laurence Fayol et al. Nutrients. .

Abstract

In preterm infants, early nutrient intake during the first week of life often depends on parenteral nutrition. This study aimed to evaluate the influence of standardized parenteral nutrition using three-in-one double-chamber solutions (3-in-1 STD-PN) on early neonatal growth in a cohort of moderately preterm (MP) infants. This population-based, observational cohort study included preterm infants admitted to neonatal centers in the southeast regional perinatal network in France. During the study period, 315 MP infants with gestational ages between 320/7 and 346/7 weeks who required parenteral nutrition from birth until day-of-life 3 (DoL3) were included; 178 received 3-in-1 STD-PN solution (56.5%). Multivariate regression was used to assess the factors associated with the relative body-weight difference between days 1 and 7 (RBWD DoL1-7). Infants receiving 3-in-1 STD-PN lost 36% less body weight during the first week of life, with median RBWD DoL1-7 of -2.5% vs. -3.9% in infants receiving other PN solutions (p < 0.05). They also received higher parenteral energy and protein intakes during the overall first week, with 85% (p < 0.0001) and 27% (p < 0.0001) more energy and protein on DoL 3. After adjusting for confounding factors, RBWD DoL1-7 was significantly lower in the 3-in-1 STD-NP group than in their counterparts, with beta (standard deviation) = 2.08 (0.91), p = 0.02. The use of 3-in-1 STD-PN provided better energy and protein intake and limited early weight loss in MP infants.

Keywords: energy; growth; moderately preterm; parenteral nutrition; premature infant; protein; standardized parenteral nutrition.

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Conflict of interest statement

The authors and collaborators declare no conflicts of interest.

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