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. 2024 Aug;26(8):101160.
doi: 10.1016/j.gim.2024.101160. Epub 2024 May 8.

Health care utilization and behavior changes after workplace genetic testing at a large US health care system

Elizabeth Charnysh  1 , Subhamoy Pal  2 , Jonathan M Reader  2 , Wendy R Uhlmann  3 , Sarah McCain  4 , Kunal Sanghavi  1 , Drew Blasco  5 , Rachael Brandt  6 , William Gregory Feero  7 , Rebecca Ferber  3 , Veda N Giri  8 , Katherine Hendy  4 , Anya E R Prince  9 , Charles Lee  10 , J Scott Roberts  11 ; INSIGHT @ Work Consortium
Collaborators, Affiliations

Health care utilization and behavior changes after workplace genetic testing at a large US health care system

Elizabeth Charnysh et al. Genet Med. 2024 Aug.

Abstract

Purpose: This study explored employee health behavior changes and health care utilization after workplace genetic testing (wGT). Wellness-program-associated wGT seeks to improve employee health, but the related health implications are unknown.

Methods: Employees of a large US health care system offering wGT (cancer, heart disease, and pharmacogenomics [PGx]) were sent electronic surveys. Self-reported data from those who received test results were analyzed. Descriptive statistics characterized responses, whereas logistic regression analyses explored correlates of responses to wGT.

Results: 53.9% (n = 418/776) of respondents (88.3% female, mean age = 44 years) reported receiving wGT results. 12.0% (n = 48/399) received results indicating increased risk (IR) of cancer, 9.5% (n = 38/398) had IR of heart disease, and 31.4% (n = 125/398) received informative PGx results. IR results for cancer and/or heart disease (n = 67) were associated with health behavior changes (adjusted odds ratio: 3.23; 95% CI 1.75, 6.13; P < .001) and health care utilization (adjusted odds ratio: 8.60; 95% CI 4.43, 17.5; P < .001). Informative PGx results (n = 125) were associated with medication changes (PGx-informative: 15.2%; PGx-uninformative: 4.8%; P = .002).

Conclusion: This study explored employee responses to wGT, contributing to the understanding of the ethical and social implications of wGT. Receiving IR results from wGT may promote health behavior changes and health care utilization in employees.

Keywords: Behavior changes; ELSI; Employees; Wellness programs; Workplace genetic testing.

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Conflict of interest statement

Conflict of Interest The authors declare no conflicts of interest.

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