Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 May 12;14(1):10835.
doi: 10.1038/s41598-024-61766-0.

Intake of oligoelements with cytarabine or etoposide alters dopamine levels and oxidative damage in rat brain

David Calderón Guzmán  1 , Norma Osnaya Brizuela  1 , Maribel Ortíz Herrera  2 , Hugo Juárez Olguín  3   4 , Armando Valenzuela Peraza  1 , Norma Labra Ruíz  1 , Gerardo Barragán Mejía  2
Affiliations

Intake of oligoelements with cytarabine or etoposide alters dopamine levels and oxidative damage in rat brain

David Calderón Guzmán et al. Sci Rep. .

Abstract

Research on the relationships between oligoelements (OE) and the development of cancer or its prevention is a field that is gaining increasing relevance. The aim was to evaluate OE and their interactions with oncology treatments (cytarabine or etoposide) to determine the effects of this combination on biogenic amines and oxidative stress biomarkers in the brain regions of young Wistar rats. Dopamine (DA), 5-Hydroxyindoleacetic acid (5-Hiaa), Glutathione (Gsh), Tiobarbituric acid reactive substances (TBARS) and Ca+2, Mg+2 ATPase enzyme activity were measured in brain regions tissues using spectrophometric and fluorometric methods previously validated. The combination of oligoelements and cytarabine increased dopamine in the striatum but decreased it in cerebellum/medulla-oblongata, whereas the combination of oligoelements and etoposide reduced lipid peroxidation. These results suggest that supplementation with oligoelements modifies the effects of cytarabine and etoposide by redox pathways, and may become promising therapeutic targets in patients with cancer.

Keywords: Brain; Cytarabine; Etoposide; Oligoelements; Oxidative damage.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Cytarabine (I) and Etoposide (II) chemical structures.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Yildiz A, Kaya Y, Tanriverdi O. Effect of the interaction between selenium and zinc on DNA repair in association with cancer prevention. J. Cancer Prev. 2019;24:146–154. doi: 10.15430/JCP.2019.24.3.146. - DOI - PMC - PubMed
    1. Ostrom QT, Cioffi G, Waite K, Kruchko C, Barnholtz-Sloan JS. CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2014–2018. Neuro Oncol. 2021 doi: 10.1093/neuonc/noab200. - DOI - PMC - PubMed
    1. Bolwell BJ, Cassileth PA, Gale RP. High dose cytarabine: A review. Leukemia. 1988;2:253–260. - PubMed
    1. Mameri A, Bournine L, Mouni L, Bensalem S, Iguer-Ouada M. Oxidative stress as an underlying mechanism of anticancer drugs cytotoxicity on human red blood cells' membrane. Toxicol. Vitro. 2021;72:105106. doi: 10.1016/j.tiv.2021.105106. - DOI - PubMed
    1. Pham NA, Hedley DW. Respiratory chain-generated oxidative stress following treatment of leukemic blasts with DNA-damaging agents. Exp. Cell Res. 2001;264:345–352. doi: 10.1006/excr.2000.5148. - DOI - PubMed

Publication types