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. 2024 Jan;72(1):63-73.
doi: 10.59556/japi.71.0440.

Current Place of SGLT2i in the Management of Heart Failure: An Expert Opinion from India

H K Chopra  1 , Tiny Nair  2 , G S Wander  3 , C K Ponde  4 , Saumitra Ray  5 , Dinesh Khullar  6 , Navin C Nanda  7 , Jagat Narula  8 , Ravi R Kasliwal  9 , D S Rana  10 , Ashok Kirpalani  11 , J P S Sawhney  12 , Praveen Chandra  13 , Yatin Mehta  14 , Viveka Kumar  15 , S Tewari  16 , A K Pancholia  17 , Vijay Kher  18 , Sandeep Bansal  19 , Sanjay Mittal  20 , Praful Kerkar  21 , P K Sahoo  22 , Ramesh Hotchandani  23 , Sunil Prakash  24 , Nagendra Chauhan  20 , Vishal Rastogi  25 , A Jabir  26 , S Shanmugasundaram  27 , Mangesh Tiwaskar  28 , Ajay Sinha  29 , Vittul Gupta  30 , S S Mishra  31 , S N Routray  32 , A K Omar  33 , Onkar C Swami  34 , Aparna Jaswal  35 , Shamsad Alam  36 , Rajeev Passey  37 , Rajeeve Rajput  38 , Justin Paul  39 , Aditya Kapoor  40 , D Prabhakar  41 , Subhash Chandra  42 , Poonam Malhotra  43 , Vivudh Pratap Singh  44 , Manish Bansal  20 , Priyank Shah  45 , Sanjay Jain  46 , Mohan Bhargava  47 , I B Vijayalakshmi  48 , Kiron Varghaese  49 , Dharmender Jain  50 , Anupam Goel  51 , Kiran Mehmood  52 , Namrata Gaur  53 , Rohit Tandon  54 , Asha Moorthy  55 , Sheeba George  56 , V K Katyal  57 , R R Mantri  58 , Rahul Mehrotra  59 , Dilip Bhalla  60 , Vinod Mittal  61 , Sarita Rao  62 , Manish Jagia  63 , Harmeet Singh  64 , Surabhi Awasthi  65 , Ameet Sattur  66 , Rekha Mishra  67 , Anand Pandey  68 , Rajeev Chawla  69 , Shalini Jaggi  70 , Blessy Sehgal  71 , Alok Sehgal  72 , Naresh Goel  73 , Ripen Gupta  74 , Samir Kubba  75 , Abhinav Chhabra  76 , Saurabh Bagga  20 , N R Shastry  77
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Current Place of SGLT2i in the Management of Heart Failure: An Expert Opinion from India

H K Chopra et al. J Assoc Physicians India. 2024 Jan.

Abstract

Heart failure (HF) is a global health concern that is prevalent in India as well. HF is reported at a younger age in Indian patients with comorbidity of type 2 diabetes (T2DM) in approximately 50% of patients. Sodium-glucose cotransporter-2 inhibitors (SGLT2i), originally approved for T2DM, are new guideline-recommended and approved treatment strategies for HF. Extensive evidence highlights that SGLT2i exhibits profound cardiovascular (CV) benefits beyond glycemic control. SGLT2i, in conjunction with other guideline-directed medical therapies (GMDT), has additive effects in improving heart function and reducing adverse HF outcomes. The benefits of SGLT2i are across a spectrum of patients, with and without diabetes, suggesting their potential place in broader HF populations irrespective of ejection fraction (EF). This consensus builds on the updated evidence of the efficacy and safety of SGLT2i in HF and recommends its place in therapy with a focus on Indian patients with HF.

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