Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Observational Study
. 2024 Oct;28(5):802-809.
doi: 10.1111/1744-9987.14137. Epub 2024 May 12.

Effect of a biomimetic pathogen adsorbing device on inflammatory biomarkers in COVID-19 patients

Jan Schmieszek  1 , Thomas Fuehner  1   2 , Isabelle Renger  1 , Tobias Welte  2 , Jan Menne  3 , Jan Fuge  2 , Maria P Van't Klooster  1 , Andrea Paul  1 , Alina Siegert  4 , Dan-Nicolae Borchina  4 , Christine S Falk  5 , Jan T Kielstein  4
Affiliations
Observational Study

Effect of a biomimetic pathogen adsorbing device on inflammatory biomarkers in COVID-19 patients

Jan Schmieszek et al. Ther Apher Dial. 2024 Oct.

Abstract

Introduction: The Seraph 100 Microbind Affinity blood filter eliminate bacteria, viruses, fungi and toxins from blood stream.

Methods: This is a prospective multicenter observational biomarker trial in PCR-positive SARS-CoV-2 patients with acute respiratory failure. Biomarkers were sequentially tested at three time points.

Results: Forty-two patients with SARS-CoV-2 detected by PCR with acute respiratory failure were included. When receiving hemoperfusion treatment, 27 (64%) patients were on mechanical ventilation, 41 (98%) patients were treated in the ICU. The 3-month survival was 52%. After one hemoperfusion treatment cycle, D-dimer (p = 0.014), hemoglobin (p = 0.003) and LDH (p = 0.001) concentrations were significantly reduced 4 days after treatment. From the multiplex assay IL-1b, CXCL8/ IL-8, IL-10, IL-13, IL-15, CCL11/Eotaxin, G-CSF, and CXCL10/IP-10 were significantly reduced 1 h after treatment, however not 4 days later.

Conclusion: Hemoperfusion with Seraph 100 Microbind Affinity Filter in patients with severe COVID-19 can transiently reduce several inflammatory biomarkers in the blood.

Keywords: COVID‐19; SARS‐CoV‐2; biomarker; hemofilter; microbind affinity filter.

PubMed Disclaimer

References

REFERENCES

    1. Polack FP, Thomas SJ, Kitchin N, Absalon J, Gurtman A, Lockhart S, et al. Safety and efficacy of the BNT162b2 mRNA Covid‐19 vaccine. N Engl J Med. 2020;383:2603–2615.
    1. Baden LR, el Sahly HM, Essink B, Kotloff K, Frey S, Novak R, et al. Efficacy and safety of the mRNA‐1273 SARS‐CoV‐2 vaccine. N Engl J Med. 2021;384:403–416.
    1. Magen O, Waxman JG, Makov‐Assif M, Vered R, Dicker D, Hernán MA, et al. Fourth dose of BNT162b2 mRNA Covid‐19 vaccine in a nationwide setting. N Engl J Med. 2022;386(17):1603–1614.
    1. The RECOVERY Collaborative Group, Horby P, Lim WS, Emberson JR, Mafham M, Bell JL, Linsel L, et al. Dexamethasone in hospitalized patients with Covid‐19. N Engl J Med. 2021;384(8):693–704.
    1. Hammond J, Leister‐Tebbe H, Gardner A, Abreu P, Bao W, Wisemandle W, et al. Oral Nirmatrelvir for high‐risk, nonhospitalized adults with Covid‐19. N Engl J Med. 2022;386(15):1397–1408.

Publication types

LinkOut - more resources