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. 1985 Apr;59(4):364-70.
doi: 10.1016/0030-4220(85)90061-1.

HLA-A, B, C, DR, MT, and MB antigens in recurrent aphthous stomatitis

G Gallina, V Cumbo, P Messina, C Caruso

HLA-A, B, C, DR, MT, and MB antigens in recurrent aphthous stomatitis

G Gallina et al. Oral Surg Oral Med Oral Pathol. 1985 Apr.

Abstract

In this report we have investigated the frequencies of HLA-A, B, C, DR, MT, and MB markers in 26 Sicilian subjects affected by recurrent aphthous stomatitis (RAS) and in 84 healthy controls. Our data show that the frequency of HLA-DR7 antigen is significantly increased in RAS-affected persons (61.5% versus 21.4%; pc less than 0.0025), whereas the B5 antigen frequency is decreased significantly (absent in patients versus 27.3% in controls; pc = 0.04). Thus, present results suggest that HLA-linked genetic factors may play a role in the development of RAS.

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