MET targeted therapy in non-small cell lung cancer patients with MET exon 14-skipping mutations
- PMID: 38736494
- PMCID: PMC11082700
- DOI: 10.21037/tlcr-24-98
MET targeted therapy in non-small cell lung cancer patients with MET exon 14-skipping mutations
Keywords: MET exon 14-skipping mutations (METex14); Non-small-cell lung cancer (NSCLC); capmatinib; companion diagnostics; tepotinib.
Conflict of interest statement
Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tlcr.amegroups.com/article/view/10.21037/tlcr-24-98/coif). J.T.J. has received consulting fees from Agilent Technologies, Alligator Biosciences, Argenx, Biovica, and Visiopharm; speaker honoraria from AstraZeneca and Leo Pharma; and royalties from Elsevier. E.M.U. reports research funding from Merck and AstraZeneca; honoraria for lectures from Amgen, AstraZeneca, Janssen, and Novartis; support from AstraZeneca and Roche for attending meeting; and is involved in the Advisory Board of Pfizer, Roche, Takeda, and AstraZeneca. J.M. is employed by and holds shares in Agilent Technologies. The authors have no other conflicts of interest to declare.
Comment on
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Tepotinib Treatment in Patients With MET Exon 14-Skipping Non-Small Cell Lung Cancer: Long-term Follow-up of the VISION Phase 2 Nonrandomized Clinical Trial.JAMA Oncol. 2023 Sep 1;9(9):1260-1266. doi: 10.1001/jamaoncol.2023.1962. JAMA Oncol. 2023. PMID: 37270698 Free PMC article. Clinical Trial.
References
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- Recondo G, Che J, Jänne PA, et al. Targeting MET Dysregulation in Cancer. Cancer Discov 2020;10:922-34. 10.1158/2159-8290.CD-19-1446 - DOI - PMC - PubMed
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