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Review
. 2024 Apr 15;12(2):52-63.
doi: 10.62347/OUJJ3710. eCollection 2024.

Trends in experimental autoimmune prostatitis: insights into pathogenesis, therapeutic strategies, and redefinition

Robbie Sj Manuel  1   2   3 , Chad M Vezina  1   2   3
Affiliations
Review

Trends in experimental autoimmune prostatitis: insights into pathogenesis, therapeutic strategies, and redefinition

Robbie Sj Manuel et al. Am J Clin Exp Urol. .

Abstract

Chronic prostatitis/chronic pelvic pain syndrome (CP/CPSS) is a debilitating condition characterized by prostate inflammation, pain and urinary symptoms. The immune system's response to self-antigens is a contributing factor to CP/CPSS. In this review, we examine the use of experimental autoimmune prostatitis (EAP) in rodents to model salient features of autoimmune mediated CP/CPSS. By exploring etiological factors, immunological mechanisms, and emerging therapeutic strategies, our aim is to enhance our understanding of CP/CPSS pathogenesis and promote the development of strategies to test innovative interventions using the EAP pre-clinical model.

Keywords: AHR; CP/CPPS; ITE; autoimmunity; experimental autoimmune prostatitis; inflammasome; inflammation; therapeutic strategies; translational animal models; urology.

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Conflict of interest statement

None.

Figures

Figure 1
Figure 1
Differential EAP induction and disease-specific symptom mimicry: antigenic variability and targeted therapies (Adopted and revised from references [4,9,21]).
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