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Review
. 2024 May 13;42(1):317.
doi: 10.1007/s00345-024-04975-6.

Conservative treatment of Peyronie's disease: a guide

Marco Cosentino  1 , Michele Di Nauta  2 , Luca Boeri  3 , Giordana Ferraioli  4 , Gianpaolo Lucignani  3 , Anna Ricapito  2 , Franco Gadda  3 , Massimo Iafrate  4 , Mariangela Mancini  4 , Fabrizio Dal Moro  4 , Eduard Ruiz-Castañe  5 , Carlo Bettocchi  2 , Emanuele Montanari  3 , Nikolaos Sofikitis  6
Affiliations
Review

Conservative treatment of Peyronie's disease: a guide

Marco Cosentino et al. World J Urol. .

Abstract

Purpose: To review the literature on the topic, to suggest a common line of treatment applicable across a wide community of specialists, and to contribute in maintaining the high level of interest in this disease.

Methods: A comprehensive and exhaustive review of the literature was performed, identifying hundreds of articles on the topic.

Results: Peyronie's disease is a condition that has been recognized, studied, and treated for centuries; despite this, if one excludes surgery in cases in which the deformity is stable, no clear treatment (or line of treatment) is available for complete relief of signs and symptoms. Treatment options were divided into local, oral, and injection therapy, and a wide variety of drugs, remedies, and options were identified.

Conclusions: Low-intensity extracorporeal shock wave therapy, vacuum therapy, penile traction therapy, phosphodiesterase type 5 inhibitors, hyaluronic acid, and collagenase of Clostridium histolyticum may be recommended only in specific contexts. Further studies on individual options or potential combinations are required.

Keywords: Acute phase; Conservative treatment; Curvature; Medical treatment; Peyronie’s disease.

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References

    1. De la Peyronie FG (1743) Sur quelques obstacles qui s’opposent a l’éjaculation naturelle de la semence. Mém Acad Roy Chir 1:318–333
    1. Levine L, Burnett AL (2013) Standard operating procedures for Peyronie’s disease. J Sex Med 10:230–244 - DOI - PubMed
    1. Chung E, Ralph D, Kagiouglu A, Garaffa G, Shamsodini A, Boivalacqua T, Glina S, Hakim L, Sadeghi-Nejad H, Broderick G (2016) Evidence-based management guidelines on Peyronie’s disease. J Sex Med 13:905–923 - DOI - PubMed
    1. Dibenedetti DB, Nguyen D, Zografos Ziemiecki R, Zhou X (2011) A population based study on Peyronie’s disease: prevalence and treatment patterns in the United States. Adv Urol. https://doi.org/10.1155/2011/282503 - DOI - PubMed - PMC
    1. Pozzi E, Capogrosso P, Boeri L, Cazzaniga W, Matloob R, Ventimiglia E, Oreggia D, Schifano N, Candela L, Abbate C, Montorsi F, Salonia A (2021) Trends in reported male sexual dysfunction over the past decade: an evolving landscape. Int J Impot Res 33(6):596–602. https://doi.org/10.1038/s41443-020-0324-7 . (Epub 2020 Jul 1) - DOI - PubMed

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