Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2024 Oct;30(4):692-694.
doi: 10.3350/cmh.2024.0346. Epub 2024 May 14.

Core protein inhibitors: Opportunities and challenges at the forefront of hepatitis B cure: Editorial on "Phase 1 trial of the safety, pharmacokinetics, and antiviral activity of EDP-514 in untreated viremic chronic hepatitis B patients"

Hae Lim Lee  1   2 , Jeong Won Jang  1   2
Affiliations
Editorial

Core protein inhibitors: Opportunities and challenges at the forefront of hepatitis B cure: Editorial on "Phase 1 trial of the safety, pharmacokinetics, and antiviral activity of EDP-514 in untreated viremic chronic hepatitis B patients"

Hae Lim Lee et al. Clin Mol Hepatol. 2024 Oct.
No abstract available

Keywords: Antiviral therapy; Core portein inhibitor; Functional cure; Hepatitis B virus.

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest

The authors have no conflicts to disclose.

Comment on

References

    1. Lok ASF. Toward a functional cure for hepatitis B. Gut Liver. 2019;18:593–601. - PMC - PubMed
    1. Zhang X, Cheng J, Ma J, Hu Z, Wu S, Hwang N, et al. Discovery of novel hepatitis B virus nucleocapsid assembly inhibitors. ACS Infect Dis. 2019;5:759–768. - PMC - PubMed
    1. Yuen MF, Chuang WL, Peng CY, Jeng WJ, Su WW, Chang TT, et al. Phase 1 trial of the safety, pharmacokinetics, and antiviral activity of EDP-514 in untreated viremic chronic hepatitis B patients. Clin Mol Hepatol. 2024;30:375–387. - PMC - PubMed
    1. Wang J, Shen T, Huang X, Kumar GR, Chen X, Zeng Z, et al. Serum hepatitis B virus RNA is encapsidated pregenome RNA that may be associated with persistence of viral infection and rebound. J Hepatol. 2016;65:700–710. - PubMed
    1. Yuen MF, Fung S, Ma X, Nguyen TT, Hassanein T, Hann HW, et al. Long-term open-label vebicorvir for chronic HBV infection: Safety and off-treatment responses. JHEP Rep. 2024;6:100999. - PMC - PubMed

LinkOut - more resources