Efficacy of Amniotic and Chorionic Membrane in Facial Wound Healing: A Comparative Study

Abstract

Background Advancements in regenerative techniques have been utilized in placental amnion and chorion for a variety of purposes. Their ability to regenerate tissues has led to their usage in tissue engineering, wound healing, and other therapeutic applications. This study aims to evaluate and compare the efficacy of amnion and chorion in facial tissue wound healing. Methodology The study was an observational comparative study conducted in the Department of Oral and Maxillofacial Surgery, involving 20 participants divided into two groups (Group I and Group II). Study groups were selected according to the inclusion and exclusion criteria. A dehydrated human amnion/ chorion membrane was applied to the affected site of each group respectively. Its efficacy in wound healing was analyzed in the first, third, seventh day, and second week. Statistical analysis was done using SPSS software (IBM Corp., Armonk, NY). Results Patients treated with amnion membrane showed a decrease in wound size and the wound was completely healed by second week with mean scores of wound sizes of 0.00 whereas the wound remained unhealed by second week with mean of 1.70 to those treated with chorion membrane. Conclusion Amnion showed superior efficacy in wound healing at two-week intervals when compared to the chorion. Hence, this could be used in regenerative medicine as a graft to induce healing in facial wounds.

Keywords: amnion; asepsis; chorion; dehydrated human amnion; facial wounds; healing rates; placental grafts; wound duration; wound healing; wound size.

Figure 1. Bar graph comparing the healing period between group1 (chorionic membrane) and group 2 (amniotic fluid)

Figure 2. (A) Before and (B) after results of chorionic membrane treatment in a 32-year-old female

*Patient consent was taken before using the images as a reference for the healing results.