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Meta-Analysis
. 2024 Dec;76(8):2745-2754.
doi: 10.1007/s13304-024-01866-8. Epub 2024 May 14.

Impact of bariatric surgery on circulating irisin levels: a systematic review and meta‑analysis

Tannaz Jamialahamdi  1   2 , Elaheh Mirhadi  3 , Wael Almahmeed  4 , Ali H Eid  5 , Khalid Al-Rasadi  6   7 , Ninh T Nguyen  8 , Kishore M Gadde  8 , Amirhossein Sahebkar  9   10   11
Affiliations
Meta-Analysis

Impact of bariatric surgery on circulating irisin levels: a systematic review and meta‑analysis

Tannaz Jamialahamdi et al. Updates Surg. 2024 Dec.

Abstract

This systematic review and meta-analysis evaluated changes in circulating irisin levels after bariatric surgery. A systematic search was performed across Embase, Scopus, PubMed, and Web of Science for this study. The meta-analysis was conducted using Comprehensive Meta-Analysis (CMA) V4 software. The overall effect size was depicted through a random-effects meta-analysis and the leave-one-out method. The meta-analysis, which included 13 studies with a total of 407 participants, showed a statistically non-significant reduction in circulating irisin levels following bariatric surgery (SMD: - 0.089, 95% CI - 0.281, 0.102, 95% PI: - 0.790, 0.611, p = 0.360; I2:70.56). Our research found no significant change in irisin levels after bariatric surgery. Moreover, these findings were not associated with the type of surgery or the duration of follow-up.

Keywords: Bariatric surgery; Irisin levels; Roux-en-Y gastric bypass; Sleeve gastrectomy.

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Conflict of interest statement

Declarations. Conflict of interest: None. Ethical approval: This article does not contain any studies with human participants or animals performed by any of the authors. Informed consent: For this type of study formal consent is not required.

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