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. 1985 Jul;82(13):4433-7.
doi: 10.1073/pnas.82.13.4433.

Inositol trisphosphate modification of ion transport in rough endoplasmic reticulum

S Muallem, M Schoeffield, S Pandol, G Sachs

Inositol trisphosphate modification of ion transport in rough endoplasmic reticulum

S Muallem et al. Proc Natl Acad Sci U S A. 1985 Jul.

Abstract

The ion transport properties of the rough endoplasmic reticulum (RER) from liver have been defined by using measurements of active and potential gradient-driven transport. The Ca2+ pump is shown to be electrogenic, and both ATP and potential difference is able to drive vanadate-inhibitable Ca2+ uptake into the RER. ATP-dependent Ca2+ transport into the RER depends on the presence of tetraethylammonium-sensitive cation conductance and a furosemide-inhibited cation/chloride cotransport pathway. Inositol trisphosphate does not affect either of the monovalent ion translocation systems but activates a Ca2+ conductance in the RER, allowing efflux of RER Ca2+ stores into the cytosol in exchange for K+ uptake.

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