Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Multicenter Study
. 2024 Sep;44(9):1335-1339.
doi: 10.1038/s41372-024-01974-8. Epub 2024 May 14.

A multicenter matched-cohort analysis of gastroschisis outcomes in infants born before 32 weeks gestation

C Preston Pugh  1 , Isabella Zaniletti  2 , Franscesca Miquel-Verges  1 , T Hang Nghiem-Rao  3 , L Corbin Downey  4 , Hannah Hightower  5 , Theresa Grover  6 , Karna Murthy  7 , Stefanie Riddle  8 , Krishna Acharya  9 ; Children’s Hospitals Neonatal Consortium Gastroschisis Focus Group
Affiliations
Multicenter Study

A multicenter matched-cohort analysis of gastroschisis outcomes in infants born before 32 weeks gestation

C Preston Pugh et al. J Perinatol. 2024 Sep.

Abstract

Objective: To examine neonatal outcomes of infants with gastroschisis born <32 weeks' gestation compared to matched infants without gastroschisis.

Study design: Retrospective matched-cohort analysis of infants with gastroschisis born <32 weeks' gestation at Children's Hospitals Neonatal Consortium (CHNC) NICUs from 2010 to 2022 compared to gestational age-matched controls.

Results: The study included 119 infants with gastroschisis and 357 matched infants; 60% of infants born 29-32 weeks, 23% born 26-28 weeks, and 16% born < 25 weeks. Mortality was not significantly different between groups (11% vs. 9%, p = 0.59). Preterm co-morbidities such as IVH, BPD, ROP, and PVL were similar, as were rates of surgical NEC. Infants with gastroschisis had longer hospital stays (92 vs. 67 days), higher CLABSI and UTIs, and were more likely to need feeding support at discharge.

Conclusion: Compared to infants without gastroschisis, infants <32 weeks' gestation with gastroschisis had similar risks for inpatient mortality, NEC, and other preterm co-morbidities.

PubMed Disclaimer

References

    1. Kirby RS, Marshall J, Tanner JP, Salemi JL, Feldkamp ML, Marengo L, et al. Prevalence and correlates of gastroschisis in 15 states, 1995 to 2005. Obstet Gynecol. 2013;122:275–81. - DOI - PubMed - PMC
    1. Jones AM, Isenburg J, Salemi JL, Arnold KE, Mai CT, Aggarwal D, et al. Increasing prevalence of gastroschisis — 14 states, 1995–2012. MMWR Morb Mortal Wkly Rep. 2016;65:23–6. - DOI - PubMed
    1. Raymond SL, Hawkins RB, St. Peter SD, Downard CD, Qureshi FG, Renaud E, et al. Predicting morbidity and mortality in neonates born with gastroschisis. J Surg Res. 2020;245:217–24. - DOI - PubMed
    1. Brebner A, Czuzoj-Shulman N, Abenhaim HA. Prevalence and predictors of mortality in gastroschisis: a population-based study of 4803 cases in the USA. J Matern Fetal Neonatal Med. 2020;33:1725–31. - DOI - PubMed
    1. Cain MA, Salemi JL, Paul Tanner J, Mogos MF, Kirby RS, Whiteman VE, et al. Perinatal outcomes and hospital costs in gastroschisis based on gestational age at delivery. Obstet Gynecol. 2014;124:543–50. - DOI - PubMed

Publication types

LinkOut - more resources