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Meta-Analysis
. 2024 May 14;24(1):162.
doi: 10.1186/s12876-024-03251-6.

Risk factors for delayed colorectal postpolypectomy bleeding: a meta-analysis

Xuzhen Zhang  1 , Xiaoxing Jiang  2 , Liang Shi  3
Affiliations
Meta-Analysis

Risk factors for delayed colorectal postpolypectomy bleeding: a meta-analysis

Xuzhen Zhang et al. BMC Gastroenterol. .

Abstract

Background: To systematically analyze risk factors for delayed postpolypectomy bleeding (DPPB) in colorectum.

Methods: We searched seven large databases from inception to July 2022 to identify studies that investigated risk factors for DPPB. The effect sizes were expressed by relative risk (RR) and 95% confidence interval (95% CI). The heterogeneity was analyzed by calculating I2 values and performing sensitivity analyses.

Results: A total of 15 articles involving 24,074 subjects were included in the study. The incidence of DPPB was found to be 0.02% (95% CI, 0.01-0.03), with an I2 value of 98%. Our analysis revealed that male sex (RR = 1.64), history of hypertension (RR = 1.54), anticoagulation (RR = 4.04), polyp size (RR = 1.19), polyp size ≥ 10 mm (RR = 2.43), polyp size > 10 mm (RR = 3.83), polyps located in the right semicolon (RR = 2.48) and endoscopic mucosal resection (RR = 2.99) were risk factors for DPPB.

Conclusions: Male sex, hypertension, anticoagulation, polyp size, polyp size ≥ 10 mm, polyps located in the right semicolon, and endoscopic mucosal resection were the risk factors for DPPB. Based on our findings, we recommend that endoscopists should fully consider and implement effective intervention measures to minimize the risk of DPPB.

Keywords: Colorectal polyps; Meta-analysis; Postoperative bleeding; Risk factors.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Flow chart of the literature screening process
Fig. 2
Fig. 2
Forest plot of delayed postpolypectomy bleeding. RR: Relative Rate
Fig. 3
Fig. 3
Funnel plot with 95% confidence limits of delayed postpolypectomy bleeding. RR: Relative Rate
See this image and copyright information in PMC

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