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Meta-Analysis
. 2024 May 14;24(1):333.
doi: 10.1186/s12887-024-04815-x.

Risk factors for hemorrhagic cystitis in children undergoing hematopoietic stem cell transplantation: a systematic review and meta-analysis

Senlin Zhang #  1 , Minyuan Liu #  1 , Qingwei Wang #  1 , Shuran Wang  1 , Xin Liu  1 , Bohan Li  1 , Jie Li  1 , Junjie Fan  2 , Shaoyan Hu  3   4
Affiliations
Meta-Analysis

Risk factors for hemorrhagic cystitis in children undergoing hematopoietic stem cell transplantation: a systematic review and meta-analysis

Senlin Zhang et al. BMC Pediatr. .

Abstract

Background: The risk factors for hemorrhagic cystitis (HC) in children undergoing hematopoietic stem cell transplantation (HSCT) are unclear. Therefore, we conducted this systematic review and meta-analysis to investigate the risk factors for HC in children undergoing HSCT.

Methods: We performed this meta-analysis by retrieving studies from PubMed, EMBASE, and the Cochrane Library up to October 10, 2023, and analyzing those that met the inclusion criteria. I2 statistics were used to evaluate heterogeneity.

Results: Twelve studies, including 2,764 patients, were analyzed. Male sex (odds ratio [OR] = 1.52; 95% confidence interval [CI], 1.16-2.00; p = 0.003, I2 = 0%), allogeneic donor (OR = 5.28; 95% CI, 2.60-10.74; p < 0.00001, I2 = 0%), human leukocyte antigen (HLA) mismatched donor (OR = 1.86; 95% CI, 1.00-3.44; p = 0.05, I2 = 31%), unrelated donor (OR = 1.58; 95% CI, 1.10-2.28; p = 0.01, I2 = 1%), myeloablative conditioning (MAC) (OR = 3.17; 95% CI, 1.26-7.97; p = 0.01, I2 = 0%), busulfan (OR = 2.18; 95% CI, 1.33-3.58; p = 0.002, I2 = 0%) or anti-thymoglobulin (OR = 1.65; 95% CI, 1.07-2.54; p = 0.02, I2 = 16%) use, and cytomegalovirus (CMV) reactivation (OR = 2.64; 95% CI, 1.44-4.82; p = 0.002, I2 = 0%) were risk factors for HC in children undergoing HSCT.

Conclusions: Male sex, allogeneic donor, HLA-mismatched, unrelated donor, MAC, use of busulfan or anti-thymoglobulin, and CMV reactivation are risk factors for HC in children undergoing HSCT.

Keywords: Children; Hematopoietic stem cell transplantation; Hemorrhagic cystitis; Risk factors.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Flow chart of study selection
Fig. 2
Fig. 2
Forest plots of the risk of hemorrhagic cystitis in children undergoing HSCT according to sex (a), allogeneic donor (b), HLA-mismatched donor (c), and unrelated donor (d) status
Fig. 3
Fig. 3
Forest plots of the risk of hemorrhagic cystitis in children undergoing HSCT according to myeloablative conditioning (MAC) (e), busulfan (f), anti-thymoglobulin (g), and cytomegalovirus (CMV) reactivation (h) status
See this image and copyright information in PMC

References

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