Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1985 Jul;69(7):497-9.
doi: 10.1136/bjo.69.7.497.

Alpha 1 antitrypsin serum levels and phenotypes in patients with retinal vasculitis

D Wakefield, J Easter, S N Breit, P Clark, R Penny

Alpha 1 antitrypsin serum levels and phenotypes in patients with retinal vasculitis

D Wakefield et al. Br J Ophthalmol. 1985 Jul.

Abstract

alpha 1 antitrypsin is an important immunoregulatory protein, the serum level of which is genetically determined. Deficient phenotypes of this ubiquitous protease inhibitor are associated with a variety of inflammatory diseases including anterior uveitis. In order to investigate the role of this protease inhibitor in the pathogenesis of retinal vasculitis (RV) 25 patients were investigated. Diseases associated with RV included Behcet's syndrome (8), SLE (2), and sarcoidosis (1). Deficient phenotypes of alpha 1 antitrypsin were not associated with RV. However, the serum alpha 1 antitrypsin level was significantly increased in patients with active RV and paralleled disease activity in patients studied prospectively.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Humangenetik. 1968;6(3):207-14 - PubMed
    1. J Lab Clin Med. 1976 Jan;87(1):152-63 - PubMed
    1. J Immunol Methods. 1977;16(3):221-31 - PubMed
    1. Lancet. 1978 May 20;1(8073):1103 - PubMed
    1. Trans Ophthalmol Soc U K. 1977 Sep;97(4):457-61 - PubMed

Substances

LinkOut - more resources