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Review
. 2024 Aug 1;36(4):437-441.
doi: 10.1097/MOP.0000000000001362. Epub 2024 May 7.

Update on the use of long-acting growth hormone in children

Margaret Cristina da Silva Boguszewski  1 , Cesar Luiz Boguszewski  2
Affiliations
Review

Update on the use of long-acting growth hormone in children

Margaret Cristina da Silva Boguszewski et al. Curr Opin Pediatr. .

Abstract

Purpose of review: After extensive research and many years of waiting, long-acting growth hormone (LAGH) formulations have finally become a reality in clinical practice and emerge as a potential solution to address the challenges of daily injections of recombinant human GH (rhGH). In this review, we present a brief history of the development of LAGH and provide a critical analysis of the existing literature on the five LAGH available and approved to date for treatment in children.

Recent findings: In clinical trials, LAGH therapy has shown noninferiority compared with daily rhGH therapy in promoting linear growth in children with GH deficiency, with similar rates of adverse events.

Summary: In the real world, many questions still need to be answered, such as whether a specific group of patients will benefit most from the weekly injection, whether compliance will be better compared with daily rhGH, whether long-term efficacy, monitoring and safety profile will be the same for the different LAGH compounds, and whether the cost-effectiveness will justify their use in different settings.

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