It ain't what you do (it's the way that you do it): modulating the host response in sepsis

Jonathan E Millar^{1

2}, Annemarie B Docherty^{3

4}

Affiliations

¹ Baillie-Gifford Pandemic Science Hub, Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK.
² Intensive Care Unit, Queen Elizabeth University Hospital, Glasgow, UK.
³ Centre for Medical Informatics, Usher Institute, University of Edinburgh, Edinburgh, UK.
⁴ Intensive Care Unit, Royal Infirmary of Edinburgh, Edinburgh, UK.

Free article

Editorial

Jonathan E Millar et al. Anaesthesia. 2024 Aug.

Free article

. 2024 Aug;79(8):792-796.

doi: 10.1111/anae.16314. Epub 2024 May 15.

Jonathan E Millar^{1

2}, Annemarie B Docherty^{3

4}

¹ Baillie-Gifford Pandemic Science Hub, Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK.
² Intensive Care Unit, Queen Elizabeth University Hospital, Glasgow, UK.
³ Centre for Medical Informatics, Usher Institute, University of Edinburgh, Edinburgh, UK.
⁴ Intensive Care Unit, Royal Infirmary of Edinburgh, Edinburgh, UK.

No abstract available

Keywords: host response; immunomodulation; sepsis; treatable traits.

References

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1. Rudd KE, Johnson SC, Agesa KM, et al. Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study. Lancet 2020; 395: 200–211. https://doi.org/10.1016/s0140‐6736(19)32989‐7.
1. Robey R, Logue C, Caird CA, et al. Immunomodulatory drugs in sepsis: a systematic review and meta‐analysis. Anaesthesia 2024. Epub 24 March. https://doi.org/10.1111/anae.16263.
1. Bone RC, Balk RA, Cerra FB, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Chest 1992; 101: 1644–1655. https://doi.org/10.1378/chest.101.6.1644.
1. Levy MM, Fink MP, Marshall JC, et al. 2001 SCCM/ESICM/ACCP/ATS/SIS international sepsis definitions conference. Crit Care Med 2003; 31: 1250–1256. https://doi.org/10.1097/01.ccm.0000050454.01978.3b.