Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 May 13;50(2):e20230343.
doi: 10.36416/1806-3756/e20230343. eCollection 2024.

Identifying malignant mesothelioma by a pathological survey using the São Paulo state hospital cancer registry, Brazil

Fabiola Del Carlo Bernardi  1 , Eduardo Algranti  2 , Marisa Dolhnikoff  3 , Clóvis Antônio Lopes Pinto  4 , Ivanir Martins de Oliveira  5 , Ester Nei Aparecida Martins Coletta  6 , Eduardo Caetano Albino da Silva  7 , Adauto José Ferreira Nunes  8 , Donaldo Botelho Veneziano  9 , Carolina Terra de Moraes Luizaga  10 , Ricardo Luiz Lorenzi  11 , Diego Rodrigues Mendonça E Silva  12 , Thais Mauad  3
Affiliations

Identifying malignant mesothelioma by a pathological survey using the São Paulo state hospital cancer registry, Brazil

Fabiola Del Carlo Bernardi et al. J Bras Pneumol. .

Abstract

Objective: To review the pathological diagnosis of possible cases and/or hidden cases of malignant mesothelioma (MM) between 2000 and 2012 using the Hospital-Based Cancer Registry database in the state of São Paulo, Brazil.

Methods: Possible cases were retrieved by assessing the database. Inclusion criteria were being older than 30 years of age and having ICD-O-3 topography and morphology codes related to MM. A board of expert pathologists reviewed the pathology reports and requested paraffin blocks in cases that demanded revision. After staining with calretinin, D2-40, WT-1 (as positive MM markers) and Ber-EP4 and MOC31 (as negative MM markers), cases were divided and studied independently by a pair of pathologists to confirm or discard the diagnosis of MM.

Results: Our sample comprised 482 cases from 25 hospitals, and 130 needed further histological revision. We received 73 paraffin blocks with adequate material. After board analysis, there were 9 cases with a definitive diagnosis of MM, improving the diagnostic rate in 12%. Two cases of previously diagnosed MM were discarded by review.

Conclusions: Our results confirm that part of MM underdiagnosis and underreporting in Brazil is due to incomplete or mistaken pathological diagnosis.

PubMed Disclaimer

Conflict of interest statement

CONFLICTS OF INTEREST: None declared.

Figures

Figure 1
Figure 1. Flow chart showing the different steps of the study. N represents reports and tissue blocks received after request to the corresponding hospitals and pathology laboratories. SP: São Paulo; and MM: malignant mesothelioma.
See this image and copyright information in PMC

References

    1. Karpathiou G, Stefanou D, Froudarakis ME. Pleural neoplastic pathology. Respir Med. 2015;109(8):931–943. doi: 10.1016/j.rmed.2015.05.014. - DOI - PubMed
    1. Lacourt A, Gramond C, Rolland P, Ducamp S, Audignon S, Astoul P. Occupational and non-occupational attributable risk of asbestos exposure for malignant pleural mesothelioma. Thorax. 2014;69(6):532–539. doi: 10.1136/thoraxjnl-2013-203744. - DOI - PubMed
    1. Baur X, Frank AL, Soskolne CL, Oliver LC, Magnani C. Malignant mesothelioma Ongoing controversies about its etiology in females. Am J Ind Med. 2021;64(7):543–550. doi: 10.1002/ajim.23257. - DOI - PubMed
    1. van Gerwen M, Alpert N, Flores R, Taioli E. An overview of existing mesothelioma registries worldwide, and the need for a US Registry. Am J Ind Med. 2020;63(2):115–120. doi: 10.1002/ajim.23069. - DOI - PubMed
    1. Marinaccio A, Binazzi A, Bonafede M, Di Marzio D, Scarselli A. Regional Operating Centres Epidemiology of malignant mesothelioma in Italy surveillance systems, territorial clusters and occupations involved. J Thorac Dis. 2018;10(Suppl 2):S221–S227. doi: 10.21037/jtd.2017.12.146. - DOI - PMC - PubMed