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Comment
. 2024 May 14;57(5):929-932.
doi: 10.1016/j.immuni.2024.04.012.

Non-canonical IKKs side with N4BP1 against the family

Dominic De Nardo  1
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Comment

Non-canonical IKKs side with N4BP1 against the family

Dominic De Nardo. Immunity. .
Free article

Abstract

The ubiquitin-binding endoribonuclease N4BP1 is a critical immunosuppressor, but the mechanism by which it acts to constrain TLR-induced inflammatory cytokine production has remained unclear. In this issue of Immunity, Gitlin et al. find that N4BP1 works in concert with the non-canonical IκB kinase (IKK) to limit activity of the IKK complex.

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Conflict of interest statement

Declaration of interests The author declares no competing interests.

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